Parham环化反应
烷基锂和芳基卤代物进行交换得到芳基锂,然后进行分子内的亲核加成得到关环产物的反应。
反应机理
为啥要两个当量?
反应实例
参考文献
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10. Gribble, G. W. Parham cyclization. In Name Reactions for Homologations-Part II; Li,J. J., Ed.; Wiley: Hoboken, NJ, 2009, pp 749-764. (Review).
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编译自:J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, Parham cyclization,page 456-457.