Cell：过敏免疫——食物的试错系统？（前沿观点） | 热心肠日报
Food allergy as a biological food quality control system
食物过敏作为一种生物性食品质量控制系统
10.1016/j.cell.2020.12.007
01-14, Review
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Food is simultaneously a source of essential nutrients and a potential source of lethal toxins and pathogens. Consequently, multiple sensory mechanisms evolved to monitor the quality of food based on the presence and relative abundance of beneficial and harmful food substances. These include the olfactory, gustatory, and gut chemosensory systems. Here we argue that, in addition to these systems, allergic immunity plays a role in food quality control by mounting allergic defenses against food antigens associated with noxious substances. Exaggeration of these defenses can result in pathological food allergy.
First Authors:
Esther B Florsheim,Zuri A Sullivan,William Khoury-Hanold
Correspondence Authors:
Ruslan Medzhitov
All Authors:
Esther B Florsheim,Zuri A Sullivan,William Khoury-Hanold,Ruslan Medzhitov