心衰患者抗阻锻炼计划和支链氨基酸补充后的身体成分变化

Clin Nutr. 2016 Feb;35(1):41-7.

Changes in body composition in heart failure patients after a resistance exercise program and branched chain amino acid supplementation.

Pineda-Juárez JA, Sánchez-Ortiz NA, Castillo-Martínez L, Orea-Tejeda A, Cervantes-Gaytán R, Keirns-Davis C, Pérez-Ocampo C, Quiroz-Bautista K, Tenorio-Dupont M, Ronquillo-Martínez A.

Instituto Nacional de Ciencias Médicas y Nutrición "SZ", Mexico City, Mexico.

Massachusetts General Hospital Interpreter Services, Boston, MA 02114, USA.

BACKGROUND & AIMS: Heart Failure (HF) is a complex syndrome, which can include the physiological, neural hormonal and metabolic complications known as "Cardiac Cachexia" (CC). In the development of CC there is a release of catabolic cytokines (Tumor Necrosis Factor-α, interleukins 1 and 6) that cause a decrease of fat free mass and fat mass. These changes in body composition might be reversed with a therapeutic combination of resistance exercise and branched chain amino acid supplementation (BCAA).

AIM: Evaluate changes in body composition after a resistance exercise program and BCAA supplementation in patients with HF.

METHODS: In a randomized clinical trial with 3 month of follow-up anthropometric body composition analysis and stress tests were evaluated at the beginning and in the end of the study. Patients were divided into two groups; the experimental group performed the resistance exercise program and received 10 g/day BCAA supplementation, and the control group only performed the resistance exercise program. Both groups were provided with individualized diets and conventional medical treatment.

RESULTS: Changes were found in hip circumference between the groups (p = 0.02), and muscle strength was increased in the experimental group (8%) and the control group (11.4%) with no difference between them. METS and VO2Max also increased in experimental and control groups (16.6% and 50.1% respectively). Regarding changes in symptoms, improvements in fatigue (45.4%), decubitus intolerance (21.8%) and dyspnea (25.4%) were observed in the overall sample.

CONCLUSION: Improvements in physical and functional capacities are attributed to resistance exercise program but not to the BCAA supplementation.

CLINICAL TRIALS IDENTIFIER: NCT02240511.

KEYWORDS: Branched chain amino acids; Heart failure; Resistance exercise

PMID: 25726428

DOI: 10.1016/j.clnu.2015.02.004