Science子刊：痤疮丙酸杆菌表达抗生素，抑制葡萄球菌在人毛囊中定植 | 热心肠日报

A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles

痤疮丙酸杆菌抗生素调节人毛囊中的皮肤菌群组成

10.1126/scitranslmed.aay5445

11-18, Article

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The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by Staphylococcus species.

First Authors:
Jan Claesen

Correspondence Authors:
Michael A Fischbach,Katherine P Lemon

All Authors:
Jan Claesen,Jennifer B Spagnolo,Stephany Flores Ramos,Kenji L Kurita,Allyson L Byrd,Alexander A Aksenov,Alexey V Melnik,Weng R Wong,Shuo Wang,Ryan D Hernandez,Mohamed S Donia,Pieter C Dorrestein,Heidi H Kong,Julia A Segre,Roger G Linington,Michael A Fischbach,Katherine P Lemon