Polonovski–Potier反应

此反应是Polonovski反应的改进反应，但是反应条件温和，C-N键没有断裂，产物得到的是β-胺基α,β-不饱和三氟甲基酮。

反应机理

反应实例

参考文献

1. Ahond, A.; Cavé, A.; Kan-Fan, C.; Husson, H.-P.; de Rostolan, J.; Potier, P. J. Am. Chem. Soc. 1968, 90, 5622–5623.

2. Husson, H.-P.; Chevolot, L.; Langlois, Y.; Thal, C.; Potier, P. J. Chem. Soc., Chem. Commun. 1972, 930–931.

3. Grierson, D. Org. React. 1990, 39, 85–295. (Review).

4. Sundberg, R. J.; Gadamasetti, K. G.; Hunt, P. J. Tetrahedron 1992, 48, 277–296.

5. Kende, A. S.; Liu, K.; Brands, J. K. M. J. Am. Chem. Soc. 1995, 117, 10597–10598.

6. Renko, D.; Mary, A.; Guillou, C.; Potier, P.; Thal, C. Tetrahedron Lett. 1998, 39,

4251–4254.

7. Suau, R.; Nájera, F.; Rico, R. Tetrahedron 2000, 56, 9713–9720.

8. Thomas, O. P.; Zaparucha, A.; Husson, H.-P. Tetrahedron Lett. 2001, 42, 3291–3293.

9. Lim, K.-H.; Low, Y.-Y.; Kam, T.-S. Tetrahedron Lett. 2006, 47, 5037–5039.

10. Gazak, R.; Kren, V.; Sedmera, P.; Passarella, D.; Novotna, M.; Danieli, B.

Tetrahedron 2007, 63, 10466–10478.

11. Nishikawa, Y.; Kitajima, M.; Kogure, N.; Takayama, H. Tetrahedron 2009, 65, 1608–1617.

12. Perry, M. A.; Morin, M. D.; Slafer, B. W.; Rychnovsky, S. D. 2012, 77, 3390–3400.

编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Polonovski–Potier reaction，page 488-489.