Science子刊：饮食改变味觉，嗜糖可能源于表观遗传变化 | 热心肠日报
[IF:13.116]
Persistent epigenetic reprogramming of sweet taste by diet
饮食对甜味味觉的持续性表观遗传重编程
10.1126/sciadv.abc8492
11-11, Article
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Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) persistently reprograms the sensory neurons of Drosophila melanogaster flies to reduce sweet sensation and promote obesity. In animals fed high sugar, the binding of PRC2.1 to the chromatin of the sweet gustatory neurons is redistributed to repress a developmental transcriptional network that modulates the responsiveness of these cells to sweet stimuli, reducing sweet sensation. Half of these transcriptional changes persist despite returning the animals to a control diet, causing a permanent decrease in sweet taste. Our results uncover a new epigenetic mechanism that, in response to the dietary environment, regulates neural plasticity and feeding behavior to promote obesity.
First Authors:
Anoumid Vaziri
Correspondence Authors:
Monica Dus
All Authors:
Anoumid Vaziri,Morteza Khabiri,Brendan T Genaw,Christina E May,Peter L Freddolino,Monica Dus