国内团队：如何利用生物活性肽防治蛀牙？ | 热心肠日报

建立一个抗生物附着和矿化的生物活性牙齿表面，以防止蛀牙并促进自我愈合

10.1021/acsami.9b19745

2019-12-26, Article

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Numerous methods have been investigated to manage dental caries, one of the top three diseases threatening human health as reported by the World Health Organization. An innovative strategy was proposed to prevent dental caries and achieve self-healing of the decayed tooth, and a novel bioactive peptide was designed and synthesized to construct an antibiofouling and mineralizing dual-bioactive tooth surface. Compared to its original endogenous peptide, the synthesized bioactive peptide showed statistically significantly higher binding affinity to the tooth surface, stronger suppression of demineralization, and a certain promotion of tooth remineralization. The abilities of the peptide to inhibit Streptococcus mutans (S. mutans) biofilm formation and S. mutans adhesion on the tooth surface were not affected after synthesis. Biocompatibility tests revealed the safety of the synthesized bioactive peptide. Interaction mechanisms between the synthesized bioactive peptide and tooth surface were also explained by molecular dynamic simulation analysis. In summary, the synthesized bioactive peptide could be applied safely to prevent dental caries and effectively induce in situ self-healing remineralization for treatment of the decayed tooth.

First Authors:
Li Zhou

Correspondence Authors:
Hai Ming Wong,Quan Li Li

All Authors:
Li Zhou,Hai Ming Wong,Yu Yuan Zhang,Quan Li Li