含氧化铁的超顺磁物质影像对比剂/活体荧光造影剂/T2对比剂（顺磁性铁锰）

含氧化铁的超顺磁物质影像对比剂/活体荧光造影剂/T2对比剂（顺磁性铁锰）

顺磁性对比剂

顺磁性对比剂由顺磁性金属元素组成，例如钆、锰、铕，但是这些都是有毒的金属元素，需要“解毒”，也就是把这些金属元素包起来，即形成该金属元素的螯合物，这样我们就可以在人体内使用，他们所含的外层电子是不成对的，因此有较大的磁矩，外加磁场存在时存在磁性，去除外加磁场时，磁性消失，即无磁滞现象，在目前使用较广泛的磁共振对比剂就是顺磁性对比剂，较多见的就是钆离子形成的螯合物，即钆对比剂。钆离子有七个未成对的电子，未成对电子自旋产生的局部磁场可以缩短临近组织氢质子的驰豫时间，在临床上主要利用的是T1驰豫效应，T2及T2效应也有应用。

超顺磁性对比剂

超顺磁性对比剂是由界于顺磁性和铁磁性之间的磁性微粒组成，这种微粒有磁畴组成，当铁磁性粒子的体积减小到使磁能小于热能时，热运动引起来的磁畴随机起伏，微粒的磁性将类似顺磁性，但是微粒的磁矩是远远要大于顺磁性物质的，因此上称之为超顺磁性微粒。有外磁场时，体现超顺磁性，外磁场消失后，磁性消失，无磁滞现象。超顺磁性对比剂的增强机制与顺磁性对比剂是不同的，超顺磁性对比剂的不成对电子的磁矩以及磁敏感性要远大于人体组织，因此造成磁场不均匀，不均匀磁场改变了横向磁化的相位，即加速了失相位，主要形成了T2及T2效应，即表现为T2WI信号减低为黑色或暗色，对T1效应影响较小。顺磁性物质的代表为铁氧化物（Fe3O4）微粒, 但是呈现为超顺磁性的微粒临界直径为30nm。

超顺磁性对比剂在实际临床应用中很多老师可能都没有见过，它可以进行灌注成像，利用的就是T2及T2效应，但是在目前实际应用中，灌注成像使用的还是顺磁性对比剂，使用快速的高浓度注射，目的也是利用了T2及T2效应。

铁磁性对比剂

铁磁性对比剂具有很高的磁化率，为具有磁矩而紧密排列的一组原子所组成的晶体，这样紧密聚集的一组原子的直径约为0.1-10μm,由于原子间的相互作用,是这些原子的磁矩排列有序形成一个远大于单个原子磁矩的永久磁矩称为磁畴，在一次磁化后,即使在没有外加磁场作用的情况下,铁磁性物质的磁畴也不是完全随机排列,故仍保持磁性。铁磁性对比剂磁矩要比顺磁性对比剂的大的多，因此造成磁场不均匀，加速了失相位，主要形成了T2及T2效应，主要体现为T2及T2效应，可以用于T2增强，可以用于灌注，制成混悬剂口服后降低消化管内液体信号可以进行消化道检查。

活体荧光造影剂

Sulfo-CY7(Cyanine7)NHSester

Sulfo-Cyanine7.5NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

sulfo-CY7(Cyanine7)maleimide

sulfo-Cyanine7.5maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)dicarboxylicacid

Sulfo-Cyanine7.5dicarboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)carboxylicacid

Sulfo-Cyanine7.5carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)azide

Sulfo-Cyanine7.5azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)alkyne

Sulfo-Cyanine7.5alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)tetrazine

Sulfo-Cyanine7tetrazine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)NHSester

Sulfo-Cyanine7NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)maleimide

Sulfo-Cyanine7maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

sulfo-CY7(Cyanine7)dicarboxylicacid

sulfo-Cyanine7dicarboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)carboxylicacid

Sulfo-Cyanine7carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)bis-NHSester

Sulfo-Cyanine7bis-NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)azide

Sulfo-Cyanine7azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)amine

Sulfo-Cyanine7amine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7)alkyne

Sulfo-Cyanine7alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)tetrazine

Cyanine7.5tetrazine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)NHSester

Cyanine7.5NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)maleimide

Cyanine7.5maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)hydrazide

Cyanine7.5hydrazide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)carboxylicacid

Cyanine7.5carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)azide

Cyanine7.5azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)azide,10mM/DMSO

Cyanine7.5azide,10mM/DMSO,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)amine

Cyanine7.5amine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)alkyne

Cyanine7.5alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)tetrazine

Cyanine7tetrazine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)NHSester

Cyanine7NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)maleimide

Cyanine7maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)hydrazide

Cyanine7hydrazide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)dicarboxylicacid

Cyanine7dicarboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)DBCO

Cyanine7DBCO,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)carboxylicacid

Cyanine7carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)azide

Cyanine7azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)azide,10mM/DMSO

Cyanine7azide,10mM/DMSO,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)amine

Cyanine7amine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7)alkyne

Cyanine7alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

BDP650/665XNHSester

BDP650/665XNHSester,Borondipyrromethenedyeforfluorescein(516nm)channel-verybrightandphotostablefluorophore.

BDP650/665maleimide

BDP650/665maleimide,Borondipyrromethenedyeforfluorescein(515nm)channel-verybrightandphotostablefluorophore.

BDP650/665azide

BDP650/665azide,Borondipyrromethenedyeforfluorescein(514nm)channel-verybrightandphotostablefluorophore.

BDP650/665alkyne

BDP650/665alkyne,Borondipyrromethenedyeforfluorescein(513nm)channel-verybrightandphotostablefluorophore.

BDP630/650XNHSester

BDP630/650XNHSester,Borondipyrromethenedyeforfluorescein(512nm)channel-verybrightandphotostablefluorophore.

BDP630/650tetrazine

BDP630/650tetrazine,Borondipyrromethenedyeforfluorescein(511nm)channel-verybrightandphotostablefluorophore.

BDP630/650maleimide

BDP630/650maleimide,Borondipyrromethenedyeforfluorescein(510nm)channel-verybrightandphotostablefluorophore.

BDP630/650hydrazide

BDP630/650hydrazide,Borondipyrromethenedyeforfluorescein(509nm)channel-verybrightandphotostablefluorophore.

BDP630/650carboxylicacid

BDP630/650carboxylicacid,Borondipyrromethenedyeforfluorescein(508nm)channel-verybrightan

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