如果miRNA的3p和5p功能不一样
看到发表在19 July 2019的文章Strand-specific miR-28-3p and miR-28-5p have differential effects on nasopharyngeal cancer cells proliferation, apoptosis, migration and invasion，全文提供实验验证了miR-28-3p and miR-28-5p的生物学功能不一样。但是我们作为数据分析人员，很难有这么复杂的背景知识，有时候仅仅是把表达矩阵给过滤，大家都懂的过滤操作。In some cases, two mature miRNAs can be excised from the same stem-loop pre-miRNAThese "5p" and "3p" miRNAs are biologically different in terms of stability and functionality. In humans, two mature miRNAs, miR-28-3p and miR-28-5p, are derived from 3′ and 5′ ends of pre-miR-28, respectively. miR-28-3p and miR-28-5p targets several cancer-related genes and is hence involved in cell proliferation, migration, invasion and epithelial–mesenchymal transition (EMT)那么问题就来了，这样的分析有意义吗？
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