iScience|多聚腺苷二磷酸核糖聚合酶(PARP)基因拷贝数的增加有利于植物长寿的进化
长寿命的有机体暴露于由于DNA损伤而累积突变的风险中。先前在动物身上的研究揭示了DNA修复基因拷贝数与寿命之间的正相关关系。然而,DNA修复在植物寿命中的作用仍不清楚。利用近年来积累的多种植物全基因组序列,对61种不同寿命的植物DNA修复基因拷贝数变异进行了系统的比较分析。在121个DNA修复基因家族中,PARP基因家族是一个独特的基因,与一年生和多年生草本植物相比,PARP基因家族在树木中表现出显著的扩展性。在植物PARPs的三个平行序列中,PARP1与生长速率密切相关。PARPs催化多聚ADP核糖基化,在DNA修复和抗病原防御中发挥关键作用。我们的研究表明PARPs在植物和动物之间的长寿中起着保守的作用。
Long-lived organisms are exposed to the risk of accumulating mutations due to DNA damage. Previous studies in animals have revealed the positive relationship between the copy number of DNA repair genes and longevity. However, the role of DNA repair in the lifespan of plants remains poorly understood. Using the recent accumulation of the complete genome sequences of diverse plant species, we performed systematic comparative analyses of the copy number variations of DNA repair genes in 61 plant species with different lifespans. Among 121 DNA repair gene families, PARP gene family was identified as a unique gene that exhibits significant expansion in trees compared to annual and perennial herbs. Among three paralogs of plant PARPs, PARP1 showed a close association with growth rate. PARPs catalyze poly(ADP-ribosyl)ation and play pivotal roles in DNA repair and antipathogen defense. Our study suggests the conserved role of PARPs in longevity between plants and animals.
https://doi.org/10.1016/j.isci.2021.102779
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