中国药科大学：压力大，伤肠道，饮食
饮食-微生物代谢的前馈循环，调节应激肠道的肠道干细胞更新
10.1038/s41467-020-20673-4
01-11, Article
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Dietary patterns and psychosocial factors, ubiquitous part of modern lifestyle, critically shape the gut microbiota and human health. However, it remains obscure how dietary and psychosocial inputs coordinately modulate the gut microbiota and host impact. Here, we show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cells (ISC) renewal and epithelial homeostasis. Chow diet (CD) and purified diet (PD) confer distinct vulnerability to gut epithelial injury, microbial alternation and ISC dysfunction in chronically restrained mice. CD preferably enriches Lactobacillus reuteri, and its colonization is sufficient to rescue stress-triggered epithelial injury. Mechanistically, dietary raffinose sustains Lactobacillus reuteri growth, which in turn metabolizes raffinose to fructose and thereby constituting a feedforward metabolic loop favoring ISC maintenance during stress. Fructose augments and engages glycolysis to fuel ISC proliferation. Our data reveal a diet-stress interplay that dictates microbial metabolism-shaped ISC turnover and is exploitable for alleviating gut disorders.
First Authors:
Yuanlong Hou
Correspondence Authors:
Xiao Zheng,Haiping Hao
All Authors:
Yuanlong Hou,Wei Wei,Xiaojing Guan,Yali Liu,Gaorui Bian,Dandan He,Qilin Fan,Xiaoying Cai,Youying Zhang,Guangji Wang,Xiao Zheng,Haiping Hao