Cell子刊：菌群如何增强宿主繁殖力？ | 热心肠日报
[IF:8.109]
Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes
菌群来源的线粒体辅酶，系统调控宿主能量和卵子生成
10.1016/j.celrep.2020.108583
01-05, Article
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Gut microbiota have been shown to promote oogenesis and fecundity, but the mechanistic basis of remote influence on oogenesis remained unknown. Here, we report a systemic mechanism of influence mediated by bacterial-derived supply of mitochondrial coenzymes. Removal of microbiota decreased mitochondrial activity and ATP levels in the whole-body and ovary, resulting in repressed oogenesis. Similar repression was caused by RNA-based knockdown of mitochondrial function in ovarian follicle cells. Reduced mitochondrial function in germ-free (GF) females was reversed by bacterial recolonization or supplementation of riboflavin, a precursor of FAD and FMN. Metabolomics analysis of GF females revealed a decrease in oxidative phosphorylation and FAD levels and an increase in metabolites that are degraded by FAD-dependent enzymes (e.g., amino and fatty acids). Riboflavin supplementation opposed this effect, elevating mitochondrial function, ATP, and oogenesis. These findings uncover a bacterial-mitochondrial axis of influence, linking gut bacteria with systemic regulation of host energy and reproduction.
First Authors:
Yulia Gnainsky
Correspondence Authors:
Yulia Gnainsky
All Authors:
Yulia Gnainsky,Nofar Zfanya,Michael Elgart,Eman Omri,Alexander Brandis,Tevie Mehlman,Maxim Itkin,Sergey Malitsky,Jerzy Adamski,Yoav Soen