营养制剂可维持肠道屏障功能（观点） | 热心肠日报

展望：保健品支持肠屏障功能的前景

10.1093/advances/nmaa139

10-30, Other

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Impairment of intestinal barrier function is linked to certain pathologies and to aging, and can be a cause of bacterial infections, systemic and hepatic inflammation, food allergies, and autoimmune disorders. The formation and maintenance of intestinal tight junctions is supported by glucagon-like peptide-2 (GLP-2), which via insulin-like growth factor I activity boosts phosphoinositide 3-kinase/Akt/mammalian target of rapamycin complex 1 (PI3K/Akt/mTORC1) signaling in enterocytes. 5′-AMP-activated protein kinase (AMPK) activity as well as estrogen receptor-β (ERβ) activity are also protective in this regard. Conversely, activation of mitogen-activated protein kinases (MAPKs) and cellular Src (c-Src) under inflammatory conditions can induce dissociation of tight junctions. Hence, nutraceuticals that promote GLP-2 secretion from L cells—effective pre/probiotics, glycine, and glutamine—as well as diets rich in soluble fiber or resistant starch, can support intestinal barrier function. AMPK activators—notably berberine and the butyric acid produced by health-promoting microflora—are also beneficial in this regard, as are soy isoflavones, which function as selective agonists for ERβ. The adverse impact of MAPK and c-Src overactivation on the intestinal barrier can be combatted with various antioxidant measures, including phycocyanobilin, phase 2–inducer nutraceuticals, and N-acetylcysteine. These considerations suggest that rationally designed functional foods or complex supplementation programs could have clinical potential for supporting and restoring healthful intestinal barrier function.

First Authors:
Mark F McCarty

Correspondence Authors:
Aaron Lerner

All Authors:
Mark F McCarty,Aaron Lerner