国内团队：清除脂多糖的肠道“清道夫”，或能防治代谢疾病 | 热心肠日报
Bio-inspired intestinal scavenger from microfluidic electrospray for detoxifying lipopolysaccharide
微流控电喷雾法制备的仿生肠道清除剂用于脂多糖的解毒
10.1016/j.bioactmat.2020.11.017
11-27, Article
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Lipopolysaccharide (LPS) plays an important role in metabolic syndrome (MetS) and other gut-derived diseases, and detoxifying LPS is considered to be a fundamental approach to prevent and treat these diseases. Here, inspired by the feeding behaviour of scavenger, novel microfluidic microcapsules with alkaline phosphatase (ALP) encapsulation and the scavenger-like molecular sieve shell are presented for cleaning intestinal LPS. Benefiting from the precisely controlled of the pore size and microfluidic electrospray, the generated microcapsules were imparted with porous molecular-sieve shells and ALP encapsulated active cores. These microcapsules could continuously work as an intestinal scavenger after colonized in intestine. It has been demonstrated that the microcapsules could englobe LPS while inhibit the permeation of digestive enzyme, and this ability contributes to promising ALP's activity, protecting cells at the presence of LPS and reducing inflammation. In addition, this scavenger inspired microcapsule could effectively decrease the LPS in organs, reduce inflammation and regulating fat metabolism in vivo. These features make the ALP encapsulated microcapsules an ideal candidate for treating MetS and other LPS related diseases.
First Authors:
Cheng Zhao
Correspondence Authors:
Yuanjin Zhao,Renjie Chai
All Authors:
Cheng Zhao,Guopu Chen,Huan Wang,Yuanjin Zhao,Renjie Chai