8种常见抗体药物偶联物(ADC)的不良反应及注意事项
抗体药物偶联物(antibody-drug conjugate,ADC)是一类通过特定的连接头将靶标特异性的单克隆抗体与高杀伤性的细胞毒性药物偶联起来的靶向生物药剂,以单克隆抗体为载体将小分子细胞毒性药物以靶向方式高效地运输至目标肿瘤细胞中。因此,近年来ADC药物一直是肿瘤精准治疗领域的热门研究方向之一。目前,全球已有8种ADC药物获得批准用于临床(包括血液系统肿瘤和实体瘤领域,表1)。
表1 已获批用于临床的ADC药物
![](http://pic.ikafan.com/imgp/L3Byb3h5L2h0dHBzL2ltYWdlMTA5LjM2MGRvYy5jbi9Eb3dubG9hZEltZy8yMDIxLzA0LzA3MTcvMjE5NTM5NTI4XzFfMjAyMTA0MDcwNTQ0MzczLnBuZw==.jpg)
由于抗体和细胞毒性药物不同,不同ADC药物的不良反应也不同。在用药期间应密切监测相应的不良反应,对可能产生严重后果的不良反应进行积极预防或给予支持治疗;在疑似发生不良症状时密切关注并及时诊断,确定发生不良反应后给予对应处置方案,同时调整药物治疗方案,进行延期治疗或减量处理,严重不良反应要及时停药;对于难以处理的不良反应,应及时开展多学科会诊,探讨解决方案。
表2 常见ADC药物相关不良反应及注意事项
![](http://pic.ikafan.com/imgp/L3Byb3h5L2h0dHBzL2ltYWdlMTA5LjM2MGRvYy5jbi9Eb3dubG9hZEltZy8yMDIxLzA0LzA3MTcvMjE5NTM5NTI4XzJfMjAyMTA0MDcwNTQ0MzcyODQucG5n.jpg)
ADC Linker产品:
cas:103750-03-45-Maleimidovalericacid-NHS
cas:1325208-25-0Mal-PEG4-NHS
cas:1260092-50-9Mal-PEG-NHS
cas:756525-99-2Mal-PEG4-NHS-ester
cas:1263044-56-9MC-PEG2-C2-NHS ester
cas:132178-37-14-pentynoic acid succinimidyl ester
cas:906564-59-85-hexynoic NHS ester
cas:944251-24-5NHS-PEG4-azide
cas:65869-64-9Bis-PEG1-NHS ester
cas:65869-63-8Bis-PEG2-NHS Ester
cas:1314378‐16‐9Bis-PEG3-NHS Ester
cas:1314378-11-4NHS-PEG3-NHS
cas:150244‐18‐1sulfo-LC-SPDP
cas:1347750-84-8MAL-Tetra-EG-OPFP
cas:1315355-92-0Mal-PEG5-NHS
cas:1137109-21-7Mal-amido-PEG6-NHS
cas:756525-93-6
cas:1137109-22-8Mal-PEG10-NHS
cas:824426-32-6Aeide-C1-NHS ester
cas:1610796-02-5NHS-PEG12-azide
cas:756526-03-1Bis-PEG5-NHS ester
cas:1008402-79-6Bis-PEG9-NHS ester
cas:870487-10-8Boc-Val-Cit-PAB-PNP
cas:55683-37-9Propargyl-PEG1-acid
cas:1174157-65-3Propargyl-PEG1-NHS ester
cas:488150-84-1Propargyl-PEG1-Boc
cas:3973-18-0Propynol Ethoxylate
cas:203740-63-0Propargyl-PEG3-bromide
cas:40842-04-4Bis-propargyl-PEG1
cas:1835759-76-6Alkyne-PEG2-methylamine
cas:1347750-80-4Alkyne-PEG4-thiol
cas:1422540-81-5Alkyne-PEG4-5-nitrophenyl carbonate
cas:89635-82-5Propargyl-PEG3-methane
cas:1872433-63-0Alkyne-PEG4-(CH2)3-methyl ester
cas:2183440-36-8APN-C3-PEG4-alkyne
cas:52436-42-7Alkyne-PEG2-acrylate
cas:2354291-37-3Gly-PEG3-endo-BCN, TFA salt
cas:2110444-63-6Boc-Gly-PEG3-endo-BCN
cas:15579-01-8Aminoethyl-SS-ethylalcohol
cas:15579-00-7Aminoethyl-SS-propionic acid
cas:51-85-4Aminoethyl-SS-ethylamine
cas:485800-26-8t-Boc-Cystamine
cas:2228857-32-5N3-SS-propionic acid
cas:2144777-72-8N3-SS-PEG2-acid
cas:2243566-44-9N3-SS-propionic NHS ester
cas:1807540-82-4N3-SS-ethylalcohol
cas:352305-38-5N3-SS-N3
cas:1310827-27-0N3-PEG3-SS-PEG3-N3
cas:2144777-83-1N3-PEG2-t-Butyl ester
cas:1391914-41-2Alkyne-PEG1-SS-alcohol
cas:1807503-85-0Alkyne-PEG1-SS-PEG1-acid
cas:1817735-30-0Alkyne-PEG1-SS-PEG1-PFP ester
cas:1964503-40-9Alkyne-PEG1-SS-PEG1-Alkyne
cas:1807518-78-0Alkyne-PEG1-SS-PEG1-t-butyl ester
cas:1807539-10-1Acid-PEG-SS-PEG-acid
cas:485800-27-9Boc-NH-ethyl-SS-propionic acid
cas:2128735-21-5Boc-aminooxy-ethyl-SS-propanol
cas:864235-83-6Fmoc-NH-ethyl-SS-propionic acid
cas:2128735-23-7Fmoc-NH-ethyl-SS-propionic NHS ester
cas:2128735-24-8Mal-NH-ethyl-SS-propionic acid
cas:5662-81-7Hydroxy-PEG3-SS-PEG3-alcohol
cas:877864-04-5THP-SS-alcohol
cas:1807503-88-3THP-SS-PEG1-t-butyl ester
cas:1807512-37-3THP-SS-PEG1-Tos
cas:1807530-16-02-hydroxyethyl disulfide mono-Tosylate
cas:69981-39-1Bis-Tos-(2-hydroxyethyl disulfide)
cas:1620523-64-9N3-SS-biotin
cas:1430408-09-5DBCO-S-S-PEG3-biotin
cas:142439-92-7Biotin-bisamido-SS-NHS
cas:122266-55-1NHS-SS-biotin
cas:325143-98-4Sulfo-NHS-SS-biotin
cas:1869922-24-6PC Biotin-PEG3-alkyne
cas:1937270-46-6PC Biotin-PEG3-N3
cas:2353409-93-3PC Biotin-PEG3-NHS carbonate ester
cas:1802907-98-7PC Alkyne-PEG4-NHS carbonate ester
cas:1408057-91-9PC Methyltetrazine-PEG4-NHS carbonate ester
cas:2353409-91-1PC N3-PEG11-NHS carbonate ester
cas:2055041-38-6Mal-PEG2-Val-Cit-PAB-OH
cas:Mal-PEG1-Val-Cit-PAB-PNP
cas:2112738-13-1Mal-amido-PEG2-Val-Cit-PAB-PNP
cas:2055024-65-0N3-PEG3-Val-Cit-PAB-OH
cas:2055047-18-0N3-PEG3-Val-Cit-PAB-PNP
cas:2353409-45-5BCN-PEG3-VC-PFP Ester
cas:1367918-21-5Methylamino-PEG1-acid
cas:1807521-03-4Methylamino-PEG1-Boc
cas:1355197-57-7Methylamino-PEG-N3 (PEG1-PEGn)
cas:85475-01-0Methylamino-PEG-Hydroxy (PEG1-PEGn)
小编:axc(西安齐岳生物)