海马NMDA受体参与大鼠自发性物体位置记忆的编码和储存而不是提取过程
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Involvement of hippocampal NMDA receptors in encoding and consolidation, but not retrieval, processes of spontaneous object location memory in rats.
背景与目的
海马被认为参与物体位置的识别和记忆，而海马NMDA受体对记忆（如编码，储存和提取)的影响并不清楚。
方 法
首先，我们观察了Wistar大鼠海马注射N-甲基-D-天冬氨酸(NMDA)受体竞争性拮抗剂2-氨基-5-磷酰基戊酸酯(AP5)后引起自发性物体位置的识别障碍；而对新物体的识别没有影响。其次，我们通过插入120分钟延迟测试方法检测了三个不同时点注射AP5处理后对物体位置识别和记忆过程的影响；即插入120分钟延迟测试方法：T1:采样前15分钟，T2:采样即刻；T3:试验前15分钟。
结 果
在采样之前和即刻，而不是在测试之前，通过阻断海马NMDA受体，大鼠对物体位置的识别表现出明显的障碍
结 论
提示海马NMDA受体在自发性物体位置记忆的编码和储存中起重要作用，而对其提取/没有影响。
原始文献摘要
Kazuo Yamadaa, Misaki Araia, Toshiko Suenagaa,b, Yukio Ichitania.⁎Involvement of hippocampal NMDA receptors in encoding and consolidation, but not retrieval, processes of spontaneous object location memory in rats. http://dx.doi.org/10.1016/j.bbr.2017.05.006 .Behavioural Brain Research 331 (2017) 14–19.
Abstract：
The hippocampus is thought to be involved in object location recognition memory, yet the contribution of hippocampal NMDA receptors to the memory processes, such as encoding, retention and retrieval, is unknown.First, we confirmed that hippocampal infusion of a competitive NMDA receptor antagonist, AP5 (2-amino-5-phosphonopentanoic acid, 20–40 nmol), impaired performance of spontaneous object location recognition test but not that of novel object recognition test in Wistar rats. Next, the effects of hippocampal AP5 treatment on each process of object location recognition memory were examined with three different injection times using a 120 min delay-interposed test: 15 min before the sample phase (Time I), immediately after the sample phase (Time II), and 15 min before the test phase (Time III). The blockade of hippocampal NMDA receptors before and immediately after the sample phase, but not before the test phase, markedly impaired performance of object location recognition test, suggesting that hippocampal NMDA receptors play an important role in encoding and consolidation/retention, but not retrieval, of spontaneous object location memory.
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