并不是只有TCGA计划里面的癌症研究才做多组学
前列腺癌是一种相对惰性的恶性肿瘤。但一旦其进入晚期,治疗将会变得十分棘手。虽然大多数晚期前列腺癌患者对内分泌治疗都有很好的反应,但在治疗18~24个月后几乎所有患者最终都将进展为去势抵抗性前列腺癌(CRPC),而一旦进展为CRPC,一半患者将难以活过两年。因此,识别哪种前列腺癌更易进入CRPC,并对此及早进行积极的综合治疗是延长生存期的重要环节。
众所周知,TCGA数据库是目前最综合最全面的癌症病人相关组学数据库,包括:
DNA Sequencing miRNA Sequencing Protein Expression array mRNA Sequencing Total RNA Sequencing Array-based Expression DNA Methylation Copy Number array
Broad Institute FireBrowse portal, The Broad Institute cBioPortal for Cancer Genomics, Memorial Sloan-Kettering Cancer Center(简称MSKCC)
nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. 拷贝数2个clusters of low- and high-risk disease beyond that achieved by Gleason score.
GSE21035 Agilent 244K aCGH data for human primary and metastatic prostate cancer samples
GSE21036 MicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate
GPL5188 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GPL8227 Agilent-019118 Human miRNA Microarray 2.0 G4470B (miRNA ID version)
描述是:Significant genomic aberrations in the prostate oncogenome from the MSKCC CGH data set adopted from (Taylor et al., 2010). Bottom: Copy number landscape of seven patient-derived organoid lines and six publically available prostate cancer cell lines using array CGH data. Shades of red and blue represent level of gain and loss.
GSM1483672 MSK-PCa2
GSM1483673 MSK-PCa3
GSM1483674 MSK-PCa4
GSM1483675 MSK-PCa5
GSM1483676 MSK-PCa6
GSM1483677 MSK-PCa7
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