低出生体重独立于遗传因素与青少年膳食摄入量改变相关：双胞胎研究

Clin Nutr. 2015 Oct 30. [Epub ahead of print]

Lower birth weight is associated with alterations in dietary intake in adolescents independent of genetic factors: A twin study.

Doornweerd S, IJzerman RG, Weijs PJ, Diamant M, de Geus EJ, Boomsma DI.

VU University Medical Centre, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.

BACKGROUND & AIMS: Lower birth weight is associated with an increased risk of cardiovascular and metabolic disease. These associations may, at least in part, be explained by alterations in dietary intake in later life. The aim of this study is to examine whether lower birth weight is associated with alterations in dietary intake in later life, and whether this association is due to intrauterine environmental or genetic factors.

METHODS: In this observational study birth weight and dietary intake were investigated in 78 dizygotic (DZ) and 94 monozygotic (MZ) adolescent same-sex twin subjects. Birth weight was obtained from the mothers. Dietary intake was assessed by two-day dietary records.

RESULTS: In the total group of twins, lower birth weight was associated with higher intake of saturated fat after adjustment for current weight (1.2 per cent of total energy intake (E%) per kg increase in birth weight, P < 0.01). Intra-pair analysis in all twin pairs demonstrated that twins with the lower birth weight had a 115 kcal higher total energy intake and a 0.7 E% higher saturated fat intake compared to their co-twins with the higher birth weight (P < 0.05). Intra-pair differences in birth weight were negatively associated with differences in energy intake and differences in intake of saturated fat after adjustment for differences in current weight (P = 0.07 and P < 0.05, respectively). Intra-pair differences in birth weight were positively associated with intra-pair differences in intake of dietary fibres (P < 0.05). These intra-pair differences and associations were similar for DZ and MZ twins (P for difference > 0.6).

CONCLUSIONS: Lower birth weight was related with higher intake of energy and saturated fat within twin pairs, and these associations were independent of zygosity, suggesting that the association between birth weight and alterations in dietary intake in later life is explained by intrauterine environmental rather than genetic factors.

KEYWORDS: Adolescents; Dietary records; Foetal origins of adult disease; Intrauterine environment; Low birth weight; Nutrition

PMID: 26575849

PII: S0261-5614(15)00266-6

DOI: 10.1016/j.clnu.2015.10.012