血清生育酚水平和维生素E摄入量与肺功能相关：标准衰老研究

　　在这项美国纵向研究（Normative Aging Study）的横断面取样调查中，饮食维生素E摄入量与肺功能正相关，γ生育酚血清水平与肺功能负相关。

Clin Nutr. 2016 Feb;35(1):169-74.

Serum tocopherol levels and vitamin E intake are associated with lung function in the normative aging study.

Hanson C, Lyden E, Furtado J, Campos H, Sparrow D, Vokonas P, Litonjua AA.

University of Nebraska Medical Center, School of Allied Health Professions, Medical Nutrition Education, 984045 Nebraska Medical Center, Omaha, NE 68198-4045, USA; University of Nebraska Medical Center, College of Public Health, 984375 Nebraska Medical Center, Omaha, NE 68198-4375, USA; Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02215, USA; Veterans Affairs Boston Healthcare System and Department of Medicine, Boston University School of Medicine, Boston, MA 02130, USA; Channing Laboratory and Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.

BACKGROUND & AIMS: The results of studies assessing relationships between vitamin E intake and status and lung function are conflicting. This study aimed to evaluate the effect of vitamin E intake and serum levels of tocopherol isoforms on lung function in a cross-sectional sample of 580 men from the Normative Aging Study, a longitudinal aging study.

METHODS: Regression models were used to look at associations of serum tocopherol isoform levels and vitamin E intake with lung function parameters after adjustment for confounders. Vitamin E intake was measured using a food frequency questionnaire and serum levels of γ, α, and δ-tocopherol levels were measured using high-performance liquid chromatography.

RESULTS: After adjustment for potential confounders, serum γ-tocopherol had a significant inverse association with forced vital capacity (β = -0.10, p = 0.05). Alpha and δ-tocopherol were not associated with any lung function parameter. After classifying COPD status according to Global Initiative for Obstructive Lung Disease (GOLD) stage criteria, serum levels of δ-tocopherol were lower in participants with more severe COPD (p = 0.01). Serum levels of δ-tocopherol were also lower in participants with greater levels of smoking (p = 0.02). Both vitamin E intake (β = 0.03, p = 0.02; β = 0.03, p = 0.01) and use of vitamin E supplements (β = 0.05, p = 0.03; β = 0.06. p = 0.02) were positively associated with FEV1 and FVC, after adjusting for confounders. Subjects who took vitamin E supplements had significantly higher α-tocopherol levels (p < 0.0001) and lower γ-tocopherol levels (p < 0.0001) than non-users.

CONCLUSION: In this study, there is a positive association between dietary vitamin E intake and lung function, and evidence of an inverse relationship between serum levels of γ-tocopherol and lung function.

KEYWORDS: COPD; Diet; Inflammation; Lung function; Tocopherols; Vitamin E

PMID: 25715694

PMCID: PMC4529394

DOI: 10.1016/j.clnu.2015.01.020