Nature：怀孕吃得多，可能是肠神经功能被重塑 | 热心肠日报
Enteric neurons increase maternal food intake during reproduction
肠神经增加繁殖期间的母体食物摄入
10.1038/s41586-020-2866-8
10-28, Article
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Reproduction induces increased food intake across females of many animal species1,2,3,4, providing a physiologically relevant paradigm for the exploration of appetite regulation. Here, by examining the diversity of enteric neurons in Drosophila melanogaster, we identify a key role for gut-innervating neurons with sex- and reproductive state-specific activity in sustaining the increased food intake of mothers during reproduction. Steroid and enteroendocrine hormones functionally remodel these neurons, which leads to the release of their neuropeptide onto the muscles of the crop—a stomach-like organ—after mating. Neuropeptide release changes the dynamics of crop enlargement, resulting in increased food intake, and preventing the post-mating remodelling of enteric neurons reduces both reproductive hyperphagia and reproductive fitness. The plasticity of enteric neurons is therefore key to reproductive success. Our findings provide a mechanism to attain the positive energy balance that sustains gestation, dysregulation of which could contribute to infertility or weight gain.
First Authors:
Dafni Hadjieconomou
Correspondence Authors:
Irene Miguel-Aliaga
All Authors:
Dafni Hadjieconomou,George King,Pedro Gaspar,Alessandro Mineo,Laura Blackie,Tomotsune Ameku,Chris Studd,Alex de Mendoza,Fengqiu Diao,Benjamin H White,André E X Brown,Pierre-Yves Plaçais,Thomas Préat,Irene Miguel-Aliaga