补充橄榄油可增加瘦子的褐色脂肪组织活性 | 热心肠日报

短期橄榄油饮食干预增加瘦个体而非超重个体的褐色脂肪组织活性

10.1210/clinem/dgaa824

11-12, Article

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Background: The brown adipose tissue is a potential target for the treatment of obesity and metabolic disorders. Its activation by cold exposure or adrenergic drugs can increase systemic insulin sensitivity and improve lipid metabolism; however, little is known about the effects of specific dietary components on brown adipose tissue activity.
Objectives: We asked if a short-term (four weeks) dietary intervention with olive oil could modify brown adipose tissue activity in lean and overweight/obese volunteers.
Design: This was a 4-week open clinical trial in which all participants underwent a dietary intervention with extra virgin olive oil supplementation. As the initial intake of olive oil was controlled all the participants were controls of themselves.
Results: The intervention resulted in significant increase in blood monounsaturated fatty acid levels, which was accompanied by increased brown adipose tissue activity in lean but not in overweight/obese volunteers. In the lean group, an increase in leptin was detected after the intervention, and low leptin values at the beginning of the study were predictive of greater brown adipose tissue activity after intervention. In addition, increase in leptin concentration was associated with increased brown adipose tissue activity. Three known endogenous mediators of brown adipose tissue activity, secretin, FGF21 and 12,13di-HOME were increased by intervention in lean, whereas only secretin and FGF21 were increased in subjects with excessive weight.
Conclusion: This study provides clinical evidence for the impact of monounsaturated fatty acids on BAT activity and an advance in the understanding of the beneficial health effects of olive oil.

First Authors:
Milena Monfort-Pires

Correspondence Authors:
Licio A Velloso

All Authors:
Milena Monfort-Pires,Mueez U Din,Guilherme A Nogueira,Juliana de Almeida-Faria,Davi Sidarta-Oliveira,Marcella Ramos Sant Ana,José C de Lima-Júnior,Dennys E Cintra,Heraldo Possolo de Souza,Sandra R G Ferreira,Marcelo Tatit Sapienza,Kirsi A Virtanen,Licio A Velloso