Key Word
Total Synthesis
Reaction development
Fundametal science
简介
Brian M. Stoltz（布莱恩 M 斯托尔茨） 出生在宾夕法尼亚州的费城。他曾就读于宾夕法尼亚印第安纳大学(Indiana University of Pennsylvania)的MBA课程，但在导师约翰·T·伍德(John T. Wood)的帮助下，他爱上了有机化学。1993年获得化学学士学位后，布莱恩在约翰·l·伍德的指导下进入耶鲁大学读研。在耶鲁大学期间，Brian完成了indolocarbazoles K252c， (+)- k252a， (+)- rk -286c， (+)- mlr -52， (-)- tan -1030a， (+)-staurosporine的全合成。1997年获得博士学位后，布莱恩随E·J·科里(E. J. Corey)教授在往哈佛大学(Harvard)，担任NIH博士后研究员。在那里，他开发了一种对映选择性合成尼可红酮天然产物的路线。完成博士后研究后，布莱恩接受了加州理工学院助理教授的职位，他现在是那里的化学教授。
荣誉奖励
Brian M. Stoltz教授至今也是收获了非常多的荣誉与奖励，列举部分：· Nankai University Lectureship, Nankai University, Tianjin, China, March 2012· R. C. Fuson Visiting Professorship, University of Illinois at Urbana-Champaign, Urbana, IL, October 2011· Caltech Academics and Research Committee (ARC) Professor of the Month, October 2011· Lester S. Andrews Lecturer, Mississippi State University, Starkville, Mississippi, May 2011· Herbert C. Brown Lecturer in Organic Chemistry, Purdue University, West Lafayette, Indiana, April 2011· Ta-shue Chou Lectureship Award, The Ta-shue Chou Foundation in conjunction with the Institute of Chemistry, Academia Sinica, Taipei, Taiwan, February 2011· Israel Chemical Society, Honorary Lifetime Member, 2010· Schulich Visiting Professor Lectureship, Technion-The Israel Institute of Technology, Haifa, Israel, 2010· Tetrahedron Young Investigator Award in Organic Chemistry, 2010 · Teva USA Scholar Awardee, 2009-2012· Givaudan-Karrer Distinguished Visiting Professor, Universität Zürich, 2009· Tetrahedron Young Investigator Award, 2010· Raymond and Beverly Sackler Prize in the Physical Sciences, 2009· Elias J. Corey Award For Outstanding Original Contribution in Organic Synthesis by a Young Investigator, 2009· KAUST Global Research Investigator, 2008· Elected as a Fellow of the American Association for the Advancement of Science (AAAS), 2006· Indiana University of Pennsylvania College of Natural Sciences and Mathematics Alumni Ambassador Award, 2006· The Associated Students of the California Institute of Technology 30th Annual Award for Excellence in Teaching, 2006· Arthur C. Cope Scholar Award from the American Chemical Society, 2005· Camille and Henry Dreyfus Teacher-Scholar Award, May 2005· 2005 Bristol-Myers Squibb Freedom to Discover Award-Unrestricted Grant in Synthetic Organic Chemistry· Tetrahedron Asymmetry Special Issue-Asymmetric Oxidation Guest Editor with Matthias Beller, 2005· Presidential Early Career Award in Science and Engineering (PECASE), 2004 (for 2002)· Novartis Chemistry Lectureship, 2004-2005· AstraZeneca, Excellence in Chemistry Award, 2004· Roche, Excellence in Chemistry Award, 2004· Gerhard Closs Lectureship, University of Chicago, 2004 · Boehringer Ingelheim New Faculty Award, 2004· Merck Research Laboratories Chemistry Council Research Award, 2000, 2001, 2002, 2004, 2005· Eli Lilly Grantee, 2004, 2005· Inaugural 21st Century of Excellence (COE) Visiting Professor, Department of Chemistry, Univerity of Tokyo, Japan, Summer 2003· Research Corporation Cottrell Scholars Award, 2003 · Amgen Young Investigator Award, 2003· Tetrahedron Symposium-in-Print Guest Editor, 2003: New Synthetic Methods· Johnson and Johnson Focused Giving Awardee, 2003, 2004 and 2005· Alfred P. Sloan Research Fellow, 2003-2005· Pfizer Research Laboratories Creativity in Synthesis Award, 2003 and 2004· GlaxoSmithKline Chemistry Scholar Award, 2002 and 2003 · Abbott Laboratories New Faculty Award, 2002 and 2003· Abbott Laboratories Lecturer, Montana State University, 2002· National Science Foundation 2002 CAREER Award, November 2001· Research Corporation 2002 Research Innovation Award, November 2001· American Chemical Society Petroleum Research Fund Type G Award, November 2001· Caltech Graduate Student Council Classroom Teaching Award, June 2001· Caltech Graduate Student Council Mentoring Award, June 2001 · Camille and Henry Dreyfus New Faculty Award, July 2000
研究领域
Natural Product Synthesis
斯托尔茨实验室的一般研究范式是利用结构复杂的目标分子作为新反应发展的驱动力。当然，这些努力不断地推进已知化学反应的边界，突出了当前技术的局限性。随之而来的综合努力不仅代表了综合战略的壮举，也代表了创造力和独创性的壮举。
Reaction development
在与具有有趣的结构和生物特性的鼓舞人心的目标合成的协同作用下，新方法的开发是我们实验室的持续动力。我们很自豪地发现利用过渡金属催化的独特反应活性，最终可用于合成复杂的自然产物。
Fundamental Science
1）Electron Diffraction Crystallography
作为与加州大学洛杉矶分校Nelson和Rodriguez实验室持续合作的一部分，我们寻求开发微晶电子衍射技术(microED)，作为小分子化学家明确的结构测定技术。
2） Computational Chemistry
在斯托尔茨团队，我们利用从头算量子力学计算来探索化学系统的基本内部工作原理。从这些调查中获得的深刻理解为反应的发展提供了一个独特的机会，以及对键结构力学的一般见解。
代表作
Total synthesis
Reaction development
Recent Publications
1)Enantioselective total synthesis of ()-myrifabral A and B
DOI: 10.1039/d0sc01141j
2)The Total Synthesis of (–)-Scabrolide A
J. Am. Chem. Soc. 2020, 142, 19, 8585–8590
3)Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis
https://science.sciencemag.org/content/363/6424/270
4)Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines
ACS Catal. 2020, 10, 5, 3241–3248
5)Cu-Catalyzed Enantioselective Allylic Alkylation with a γButyrolactone-Derived Silyl Ketene Acetal.
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201912618
5)Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of 1,4-Diazepan-5-ones
Org. Lett. 2019, 21, 22, 9158–9161
人才培养
Brian M. Stoltz师从有机逆合成理论大师 E. J. Corey，目前在加州理工学院担任化学教授，承前启后地，他也培养了大量化学人才，列举部分：
评述
Brian M. Stoltz师从有机逆合成理论大师 E. J. Corey，目前在加州理工学院担任化学教授，他专注与天然产物的全合成与基于金属钯（Pd)、钇(Ir)、镍(Ni)、铜(Cu)催化方法的开发，并且深入研究基础化学领域。他带领的团队在天然产物全合成和新方法学的开发上建树颇丰。
参考
https://www.stoltz.caltech.edu/
https://academictree.org/
