2020年医学生信分析别人都在用哪些思路？
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一. 生信友好杂志详解
带你了解
①Aging现在的状况如何？
②Aging成了纯生信灌水的乐园？
2.即将突破5分的Frontiers in Oncology是灌水杂志吗？
带你了解
①Front Oncol发表的生信文章的文章类型为哪几类？
②纯生信文章的发表周期如何？
3.马上4分年刊近2000的杂志JCB：对纯生信友好还不要版面费！
一文速览
①JCB的纯生信文章分类
②投稿建议
一文速览
①JCP的投稿类型范围
②纯生信文章分类
③投稿周期
二.生信思路详解
①数据集筛选原则
②Case1: 肿瘤预后基因
③Case2: Risk Score
④Case3: 耐药基因
①Case1:预后标志物+免疫浸润
②Case2:单基因多组学验证生存
③Case3:基因突变+TMB+免疫浸润
①理清研究方向
②举例
③生信分析注意事项
三.生信文章详解(标志物&分型&建模)
常规转录组类
(一)表达谱预后
A robust two‐gene signature for glioblastoma survival prediction
Autophagy-related gene P4HB: a novel diagnosis and prognosis marker for kidney renal clear cell carcinoma
Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinomae
Landscape of cancer diagnostic biomarkers from specifically expressed genes
(二)肿瘤免疫微环境或免疫相关类
Immune cell infiltration-based signature for prognosis and immunogenomic analysis in breast cancer
EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients
Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics
Immune gene expression profiling reveals heterogeneity in luminal breast tumors
(三)ceRNA
Identification of the Key Factors Related to Bladder Cancer by lncRNA-miRNA-mRNA Three-Layer Network
单细胞转录组类
Single-cell RNA sequencing of immune cells in gastric cancer patients
Single-cell RNA sequencing of human kidney
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
表观遗传类
(一)m6A
m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer
Identification of cross-talk between m6A and 5mC regulators associated with onco-immunogenic features and prognosis across 33 cancer types
(二)甲基化
Methylome and transcriptome analyses reveal insights into the epigenetic basis for the good survival of hypomethylated ER-positive breast cancer subtype
干湿结合类
Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival
A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis
基因组类
突变预后
The pan-cancer landscape of prognostic germline variants in 10,582 patients
Interpretation of somatic POLE mutations in endometrial carcinoma
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