国内团队：口腔菌群干预或能协助前列腺疾病治疗（综述） | 热心肠日报
[IF:9.3]
A potential therapeutic strategy for prostatic disease by targeting the oral microbiome
口腔菌群为靶点治疗前列腺疾病的潜在策略
10.1002/med.21778
2020-12-30, Review
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Nowadays, human microbiome research is rapidly growing and emerging evidence has witnessed the critical role that oral microbiome plays in the process of human health and disease. Oral microbial dysbiosis has been confirmed as a contributory cause for diseases in multiple body systems, ranging from the oral cavity to the gastrointestinal, endocrine, immune, cardiovascular, and even nervous system. As research progressing, oral microbiome‐based diagnosis and therapy are proposed and applied, which may represent potential drug targets in systemic diseases. Recent studies have uncovered the possible association between periodontal disease and prostatic disease, suggesting new prevention and therapeutic treatment for the disease by targeting periodontal pathogens. Thus, we performed this review to first explore the association between the oral microbiome and prostatic disease, according to current knowledge based on published articles, and then mainly focus on the underlying molecular and cellular mechanisms and the potential prevention and treatment derived from these mechanistic studies.
First Authors:
Cheng Fang
Correspondence Authors:
Hailiang Hu,Xian‐Tao Zeng
All Authors:
Cheng Fang,Lan Wu,Cong Zhu,Wen‐Zhong Xie,Hailiang Hu,Xian‐Tao Zeng