复方亚甲蓝局部封闭联合中医药治疗肛周湿疹有效性和安全性的Meta分析

复方亚甲蓝局部封闭联合中医药治疗肛周湿疹有效性和安全性的Meta分析

英文题名：A Meta-analysis of safety and efficacy of local blocking with the Fufang Yajialan injection plus TCM medicine on perianal eczema

作者：王茹茹，宋太平，李建国

英文作者：Wang Ruru

期刊名： 中医临床研究

作者单位：河南中医药大学；郑州市大肠肛门病医院

年份：2020

页 码：P5-10

期号： 第4期

卷 号：第12卷

英文关键词：The Fufang Yajialan injection;Local blocking;Perianal eczema;Randomized controlled trials;A Meta-analysis

摘要

目的:系统评价复方亚甲蓝局部封闭联合中医药治疗肛周湿疹的有效性和安全性。方法:计算机检索中国知网(CNKI),维普中文期刊数据库(VIP),万方数字化期刊全文数据库,中国生物医学文献数据库,Embase,Pub Med,Cochrane Library,收集复方亚甲蓝局部封闭联合中医药治疗肛周湿疹的临床随机对照研究,检索时限均为从建库至2019年5月。采用Rev Man.5.3软件进行数据分析。结果:共纳入22个随机对照试验,共计2 211例肛周湿疹患者。Meta分析显示:与常规治疗组相比,复方亚甲蓝局部封闭联合中医药治疗肛周湿疹在提高有效率、改善症状(瘙痒程度、渗出潮湿、皮损面积、皮损形态),降低症状体征总积分、减少复发率具有明显意义(P 0.05);对降低不良反应发生率方面无明显意义(P=0.41> 0.05),未见复方亚甲蓝局部封闭联合中药应用严重不良反应报道。结论:基于目前检索的文献及Meta分析结果,复方亚甲蓝局部封闭联合中医药治疗肛周湿疹的疗效在一定程度上优于常规疗法。但由于纳入研究的方法学质量偏低,证据质量低,临床治疗中可以借鉴应用,但仍需高质量的随机对照试验(Randomized Controlled Trial,RCT)进行验证。

外文提要

Objective: To evaluate safety and efficacy of local blocking with the Fufang Yajialan injection( 复方亚甲蓝注射液)plus TCM medicine on perianal eczema. Methods: The databases was searched in CNKI, VIP and WANFANG DATA, SinoMed Embase, PubMed, Cochrane Library. The search time ranged from building database to May 2019. Data was analyzed by RveMan.5.3 software. Results: There were 22 RCTs enclosed involving 2 211 patients.The Meta-analysis showed that the Fufang Yajialan injection plus TCM medicine was more effective on symptoms, total score of symptoms, and recurrence rate(P0.05), and no significant effect on adverse reactions(P=0.41>0.05). No serious bad effects were reported about the Fufang Yajialan injection. Conclusion: The Fufang Yajialan injection plus TCM medicine on perianal eczema was more effective. Due to the low quality of methodologies included in the study, the quality of evidence is mainly in the middle and lower grades, and the method can be applied in the clinic, while the high RCTs are needed to verify.