饮食如何调控肠道干细胞与大肠癌（综述） | 热心肠日报
Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis
肠干细胞在稳态和肿瘤发生中的营养控制
10.1016/j.tem.2020.11.003
12-01, Review
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Food and nutrition have a profound impact on organismal health and diseases, and tissue-specific adult stem cells play a crucial role in coordinating tissue maintenance by responding to dietary cues. Emerging evidence indicates that adult intestinal stem cells (ISCs) actively adjust their fate decisions in response to diets and nutritional states to drive intestinal adaptation. Here, we review the signaling mechanisms mediating the dietary responses imposed by caloric intake and nutritional composition (i.e., macronutrients and micronutrients), fasting-feeding patterns, diet-induced growth factors, and microbiota on ISCs and their relevance to the beginnings of intestinal tumors.
First Authors:
Gizem Calibasi-Kocal,Omid Mashinchian
Correspondence Authors:
Chia-Wei Cheng,Omer H Yilmaz
All Authors:
Gizem Calibasi-Kocal,Omid Mashinchian,Yasemin Basbinar,Ender Ellidokuz,Chia-Wei Cheng,Omer H Yilmaz