Nature：一吃特定食物就腹痛？可能是肠道免疫细胞“搞错了” | 热心肠日报
Local immune response to food antigens drives meal-induced abdominal pain
对食物抗原的局部免疫反应导致进食引起的腹痛
10.1038/s41586-020-03118-2
01-13, Article
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Up to 20% of people worldwide develop gastrointestinal symptoms following a meal1, leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific and lay communities in this issue has increased markedly in recent years, with the worldwide introduction of gluten-free and other diets, the underlying mechanisms of food-induced abdominal complaints remain largely unknown. Here we show that a bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine. Following subsequent oral ingestion of the respective dietary antigen, an IgE- and mast-cell-dependent mechanism induced increased visceral pain. This aberrant pain signalling resulted from histamine receptor H1-mediated sensitization of visceral afferents. Moreover, injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with irritable bowel syndrome induced local oedema and mast cell activation. Our results identify and characterize a peripheral mechanism that underlies food-induced abdominal pain, thereby creating new possibilities for the treatment of irritable bowel syndrome and related abdominal pain disorders.
First Authors:
Javier Aguilera-Lizarraga,Morgane V Florens
Correspondence Authors:
Alexandre Denadai-Souza,Mira M Wouters,Guy E Boeckxstaens
All Authors:
Javier Aguilera-Lizarraga,Morgane V Florens,Maria Francesca Viola,Piyush Jain,Lisse Decraecker,Iris Appeltans,Maria Cuende-Estevez,Naomi Fabre,Kim Van Beek,Eluisa Perna,Dafne Balemans,Nathalie Stakenborg,Stavroula Theofanous,Goele Bosmans,Stéphanie U Mondelaers,Gianluca Matteoli,Sales Ibiza Martínez,Cintya Lopez-Lopez,Josue Jaramillo-Polanco,Karel Talavera,Yeranddy A Alpizar,Thorsten B Feyerabend,Hans-Reimer Rodewald,Ricard Farre,Frank A Redegeld,Jiyeon Si,Jeroen Raes,Christine Breynaert,Rik Schrijvers,Cédric Bosteels,Bart N Lambrecht,Scott D Boyd,Ramona A Hoh,Deirdre Cabooter,Maxim Nelis,Patrick Augustijns,Sven Hendrix,Jessica Strid,Raf Bisschops,David E Reed,Stephen J Vanner,Alexandre Denadai-Souza,Mira M Wouters,Guy E Boeckxstaens