研究肠道菌群组成和功能的新兴计算工具和模型（综述） | 热心肠日报
Emerging computational tools and models for studying gut microbiota composition and function
用于研究肠道菌群组成和功能的新兴计算工具和模型
10.1016/j.copbio.2020.10.005
2020-11-25, Article
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The gut microbiota and its metabolites play critical roles in human health and disease. Advances in high-throughput sequencing, mass spectrometry, and other omics assay platforms have improved our ability to generate large volumes of data exploring the temporal variations in the compositions and functions of microbial communities. To elucidate mechanisms, methods and tools are needed that can rigorously model the dependencies within time-series data. Longitudinal data are often sparse and unevenly sampled, and nontrivial challenges remain in determining statistical significance, normalization across different data types, and model validation. In this review, we highlight recent developments in models and software tools for the analysis of time series microbiome and metabolome data, as well as integration of these data.
First Authors:
Seo-Young Park,Arinzechukwu Ufondu
Correspondence Authors:
Kyongbum Lee,Arul Jayaraman
All Authors:
Seo-Young Park,Arinzechukwu Ufondu,Kyongbum Lee,Arul Jayaraman