独家专访 | 港科大团队开发全脑基因编辑技术,可跨越血脑屏障,已验证可改善小鼠AD症状
首次非侵入方式实现全脑基因编辑
“将关注全脑基因编辑的安全性”
参考资料:
Yangyang Duan, Tao Ye, Zhe Qu, Yuewen Chen, Abigail Miranda, Xiaopu Zhou, Ka-Chun Lok, Yu Chen, Amy K. Y. Fu, Viviana Gradinaru, Nancy Y. Ip. Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice. Nature Biomedical Engineering, 2021; DOI: 10.1038/s41551-021-00759-0 https://www.synthego.com/blog/alzheimers-crispr
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