Stobbe condensation

丁二酸二乙酯及其衍生物和羰基化合物在碱性条件下进行缩合的反应。

反应机理

丁二酸二乙酯先对羰基化合物进行aldol加成，接着形成内酯，强碱拔氢消除开环得到产物。

反应实例

Stobbe缩合后产物缩合。

Stobbe产物的关环反应。

连续的Stobbe缩合。

参考文献

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编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Stobbe condensation，page 587-588.