Lancet子刊：显微镜下结肠炎的病理生理学和临床治疗（综述） | 热心肠日报
[IF:N/A]
Microscopic colitis: pathophysiology and clinical management
显微镜下结肠炎：病理生理学与临床治疗
10.1016/S2468-1253(19)30048-2
2019-03-21, Review
Abstract & Authors:展开
Abstract:收起
Microscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes can be distinguished—collagenous colitis and lymphocytic colitis—but incomplete and variant forms with fewer characteristic features have been reported. Here we summarise the latest evidence on epidemiology, pathogenesis, and risk factors, and discuss established and novel therapeutic options for clinical remission. Finally, we propose an updated treatment algorithm. Further prospective studies are needed to clarify the natural history of microscopic colitis, supported by validated criteria for the assessment of disease activity
First Authors:
Stephan Miehlke
Correspondence Authors:
Stephan Miehlke
All Authors:
Stephan Miehlke,Bas Verhaegh,Gian Eugenio Tontini,Ahmed Madisch,Cord Langner,Andreas Münch