热平衡有助于小鼠对肠道疾病的耐受性 | 热心肠日报
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance
产热脂肪-上皮细胞轴调节肠道疾病耐受性
10.1073/pnas.2012003117
11-30, Article
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Disease tolerance, the capacity of tissues to withstand damage caused by a stimulus without a decline in host fitness, varies across tissues, environmental conditions, and physiologic states. While disease tolerance is a known strategy of host defense, its role in noninfectious diseases has been understudied. Here, we provide evidence that a thermogenic fat–epithelial cell axis regulates intestinal disease tolerance during experimental colitis. We find that intestinal disease tolerance is a metabolically expensive trait, whose expression is restricted to thermoneutral mice and is not transferable by the microbiota. Instead, disease tolerance is dependent on the adrenergic state of thermogenic adipocytes, which indirectly regulate tolerogenic responses in intestinal epithelial cells. Our work has identified an unexpected mechanism that controls intestinal disease tolerance with implications for colitogenic diseases.
First Authors:
Kevin Man
Correspondence Authors:
Kevin Man,Ajay Chawla
All Authors:
Kevin Man,Christopher Bowman,Kristina N Braverman,Veronica Escalante,Yuan Tian,Jordan E Bisanz,Kirthana Ganeshan,Biao Wang,Andrew Patterson,James R Bayrer,Peter J Turnbaugh,Ajay Chawla