病害改变了植物微生物组装和功能适应性
写在前面
土壤真菌植物病原体利用效应蛋白操纵微生物组
Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteins
第一作者:
Nick C. Snelders
通讯作者:
Bart P. H. J. Thomma
摘要
在宿主定植过程中,病原体分泌效应蛋白,通过多种机制促进疾病发生。越来越多的证据表明,宿主微生物群在健康中起着至关重要的作用,宿主积极招募并控制微生物群以抑制疾病。我们提出病原体进化是为了操纵宿主微生物群,从而反过来为自己的利益服务。在这篇文章中,我们发现了之前鉴定的毒力效应体VdAvel,由植物病原黄萎病菌(Verticillium dahliae)分泌,显示出抗菌活性,并通过操纵它们来促进番茄和棉花的定殖。使得微生物群落可以抑制拮抗细菌。此外,我们还发现VdAvel和新发现的抗菌效应子VdAMP2被用于控制土壤环境中的微生物群落,在这些环境中,真菌在没有宿主的情况下生存。总之,我们证明了真菌植物病原利用效应蛋白来调节宿主体内和体外的微生物群落组成,并提出了病原菌效应蛋白策略为新抗生素提供了一个未开发的资源。
During colonization of their hosts, pathogens secrete effector proteins to promote disease development through various mechanisms. Increasing evidence shows that the host microbiome plays a crucial role in health, and that hosts actively shape theirmicrobiomes to suppress disease. We proposed that pathogens evolved to manipulate host microbiomes to their advantage inturn. Here, we show that the previously identified virulence effector VdAve1, secreted by the fungal plant pathogen Verticilliumdahliae, displays antimicrobial activity and facilitates colonization of tomato and cotton through the manipulation of theirmicrobiomes by suppressing antagonistic bacteria. Moreover, we show that VdAve1, and also the newly identified antimicrobialeffector VdAMP2, are exploited for microbiome manipulation in the soil environment, where the fungus resides in absence of ahost. In conclusion, we demonstrate that a fungal plant pathogen uses effector proteins to modulate microbiome compositionsinside and outside the host, and propose that pathogen effector catalogues represent an untapped resource for new antibiotics.
主要图表
图表1 . dahliae effector VdAve1的抗菌活性
Antibacterial activity of V. dahliae effector VdAve1.
图表2 V. dahliae VdAve1 影响微生物组
Fig. 2 | V. dahliae VdAve1 affects microbiomes
图表3 V. dahliae VdAve1 影响
鞘翅目科 的抗菌活性
Fig. 3 | V. dahliae VdAve1 affects antagonistic Sphingomonads
图表4 VdAMP2 有助于V. dahliae在土壤中定植
Fig. 4 | VdAMP2 contributes to V. dahliae soil colonization
根际互作生物学研究室 简介
根际互作生物学研究室是沈其荣教授土壤微生物与有机肥团队下的一个关注于根际互作的研究小组。本小组由袁军副教授带领,主要关注:1.植物和微生物互作在抗病过程中的作用;2 环境微生物大数据整合研究;3 环境代谢组及其与微生物过程研究体系开发和应用。团队在过去三年中在 isme J, Microbiome, PCE,SBB,Horticulture Research等期刊上发表了多篇文章。欢迎关注 微生信生物 公众号对本研究小组进行了解。
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