Nature子刊：维生素D代谢与肠道菌群的关联 | 热心肠日报
[IF:12.121]
Vitamin D metabolites and the gut microbiome in older men
老年人的维生素D代谢产物与肠道菌群
10.1038/s41467-020-19793-8
11-26, Article
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The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA gene sequencing data. Faith’s Phylogenetic Diversity and non-redundant covariate analyses reveal that the serum 1,25(OH)2D level explains 5% of variance in α-diversity. In β-diversity analyses using unweighted UniFrac, 1,25(OH)2D is the strongest factor assessed, explaining 2% of variance. Random forest analyses identify 12 taxa, 11 in the phylum Firmicutes, eight of which are positively associated with either 1,25(OH)2D and/or the hormone-to-prohormone [1,25(OH)2D/25(OH)D] “activation ratio.” Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health.
First Authors:
Robert L Thomas,Lingjing Jiang
Correspondence Authors:
Deborah M Kado
All Authors:
Robert L Thomas,Lingjing Jiang,John S Adams,Zhenjiang Xu,Jian Shen,Stefan Janssen,Gail Ackermann,Dirk Vanderschueren,Steven Pauwels,Rob Knight,Eric S Orwoll,Deborah M Kado