益生菌对体重和体重指数的影响：随机对照试验系统回顾与荟萃分析

　　2016年8日，英国泰勒与弗朗西斯出版集团旗下《国际食品科学与营养杂志》第67卷第5期将正式发表泰州市人民医院的随机对照试验系统回顾与荟萃分析，发现摄入益生菌可减轻体重和体重指数。

　　益生菌对消化系统健康的益处已经得到广泛认可。益生菌补充剂经常被加入酸奶，可提高免疫力。然而，一直缺乏益生菌有益于体重和体重指数的证据。既往大量研究调查了益生菌对体重和体重指数的影响，但无一致结果。

　　该系统回顾与荟萃分析包括20项研究25项随机对照试验共1931位年龄＞18岁的参与者，调查益生菌对体重和体重指数的影响。

　　结果发现，补充益生菌可使体重降低0.59kg（95%置信区间：0.30～0.87）、体重指数降低0.49kg/m²（95%置信区间：0.24～0.74）。亚组分析显示，摄入益生菌种类＞1种或时间≥8周，体重指数降低更显著（P＜0.01）。敏感性分析显示，超重（体重指数≥25kg/m²）者降幅最大（P＜0.01）。

　　该系统回顾与荟萃分析最重要的发现是，根据25项随机对照试验，发现益生菌确实可致体重和体重指数下降，尤其对于摄入益生菌种类＞1种或时间≥8周或超重者。

Int J Food Sci Nutr. 2016 Aug;67(5):571-80.

Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials.

Zhang Q, Wu Y, Fei X.

Taizhou People's Hospital, Taizhou, China.

OBJECTIVE: To assess the efficacy of probiotic therapies on body weight and BMI using a meta-analysis of randomized, controlled trials.

METHODS: Twenty studies with 25 trials (1931 participants with age over 18 years) were included. The pooled WMD was calculated by random effects model.

RESULTS: Probiotic consumption significantly reduced body weight by 0.59 kg (95% CI, 0.30-0.87) and BMI by 0.49 kg/m(2) (95% CI, 0.24-0.74). A greater reduction in BMI was found with multiple species of probiotics. Subgroup analysis of trials with intervention duration ≥8 weeks found a more significant reduction in BMI. Limiting analysis to trials with a baseline BMI ≥25 kg/m(2) showed a greater reduction in BMI.

CONCLUSION: Consuming probiotics could reduce body weight and BMI, with a potentially greater effect when multiple species of probiotics were consumed, the duration of intervention was ≥8 weeks, or the objects were overweight.

KEYWORDS: BMI; meta-analysis; obesity; overweight; probiotics

PMID: 27149163

DOI: 10.1080/09637486.2016.1181156