十年一剑：北大脑研究所
2011年，北京大学建立IDG/麦戈文脑研究所。
至今十年。
本文目录：
1） 小结
2） 起源
3）十周年学术报告会日程
4 ）附件一 林建华常务副校长2009年的PPT（部分）
5 ）附件二 周其凤校长2010年致信麦戈文夫妇和MIT麦戈文脑研究所所长
6 ）附件三 2010年北京大学脑研究所提议
1）小结
北大脑研究所，从来没有举办过任何仪式，只有实事的推进。
十年来，它成为北京大学脑科学研究的核心，它联合了全校的相关科学家和机构，它支持了学科交叉，它国际招聘了多位研究员，它让脑科学在北京大学不断成长壮大。
(北大脑研究所大部分研究员十年第一次合影）
它的研究员遍布：心理与认知学院(16位)、生命科学学院(10位)、医学院(7位)、化学学院(1位)、物理学院(1位)、计算机学院(1位)、未来技术学院(2位)、药学院(1位)、精神病院(4位)。
它研究的问题涵盖：神经生物、心理、认知、基础医学、临床医学、新药…
它实验的手段包括：分子生物学、遗传学、基因分析、心理分析、光学成像、磁成像、光学操纵、磁操纵、计算…
它研究的层面包括：分子、细胞、系统、个体、群体。
十年来，它鼓励师生自由探索，它平时不干预师生的学术研究，它只对研究员每五年一次国际学术质量评估，它也从来不浪费时间举行任何非学术的活动。
十年来，它最突出的研究是发明GPCR探针，为中国广义的脑科学有史以来在世界上最重要的技术发明成果。
它的师生快乐地探寻脑和神经系统的奥秘；
它有信心为人类做出有更多、更大的贡献。
2）起源
Patrick McGovern先生，毕业于麻省理工学院，对神经科学长期感兴趣，他以三亿美元支持麻省理工学院建立麦戈文脑研究所。
他长期与中国交往，一生访问中国一百多次。
他和他的企业IDG，考虑在亚洲支持脑研究所。
当时清华大学校长陈吉宁力促麦戈文夫妇在中国支持脑研究所。
IDG的熊晓鸽也力劝。
这些因素和促进，加快了麦戈文夫妇和IDG决定在中国支持脑研究所。
2008年8月8日，奥运会在北京开幕。
同日，麦戈文夫妇致信中国大学和科研机构，邀请竞争脑研究所的支持。
中国正式参与竞争的是北大、清华、北师大和中国科学院生物物理研究所。科学院给生物物理所最大的支持，其中匹配最多。为此，科学院副院长和所长赴美国麻省理工。
北京大学于2009年2月9日接待麦戈文夫妇一行。
周其凤校长主持接待，林建华常务副校长PPT演讲（PPT的部分内容见后的附件一）。
2010年7月3日，周其凤校长正式提交北大脑科学研究所提议。(附件二和三)
2011年，北京大学-麦戈文/IDG脑科学研究所成立。
因为当时我任生命科学学院的院长，为了避免利益冲突，我将脑研究所挂靠当时的心理系（后来的心理与认知学院）。这样，不仅脑研究所没有影响生命科学学院，不能将院长自己的专业成为学院最大的专业，而且积极地支持了心理学院的成长。脑研究所一直挂靠心理和认知学院，对于心理的招聘、空间发展和经费都有很好的支持，做到了平衡发展北大的重要学科和院系。
3） 十周年学术报告会日程
4） 附件一 林建华常务副校长2009年的PPT(饶毅部分参与)
...
...
5 ）附件二 周其凤校长2010年的提议信(饶毅写)
July 3, 2010
Mr. and Mrs. Patrick and Lore McGovern
c/o
Dr. Robert Desimone
Director, McGovern Institute
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02139
USA
Dear Mr. and Mrs. Patrick and Lore McGovern,
Thank you very much for your letter of August 8th 2008 inviting Peking University (PKU) to submit a proposal for a McGovern Institute for Brain Research (MIBR) in China.
PKU welcome the prospect of hosting a MIBR at PKU. We treasure the opportunity and will make every effort to ensure its success.
I was pleased to host you on February 9, 2009, which was one of my first duties as the new president of PKU. I consider it a high priority to establish a world class research institute that will further our understanding of fundamental principles of brain function and help alleviate human sufferings resulting from brain malfunctioning.
I hope that you will find that, both academically and strategically, PKU is the best site for MIBR in China.
PKU has a unique history in integrating the best of the West with the best of the East. PKU is the successful combination of two universities (one Chinese and one American); the academic disciplines actively pursued by our faculty and students range from Chinese (and Western) classics to cutting edge science; our beautiful buildings of traditional Chinese style were designed by an American architect in the 1920s.
The overall strength of PKU in neuroscience is unparalleled in China. Other institutions may have parts of what we have, but none comes close to match the key components that will be pillars for supporting a future McGovern Institute. PKU is the only Chinese institution with active neuroscience research ranging from the molecular to the cognitive, from the physiological to the pathological. PKU has the largest academic psychiatric hospital in China, actively involved in genetic studies of schizophrenia and autism. It will take years for other Chinese institutions to establish such a hospital and build up similar research profile and strength. PKU has the first and only primate center at a Chinese university that has been internationally certified for research. PKU has the first chemical biology department in the country. PKU has founded an MRI center for brain research with participation from both the physics and psychology departments. These resources and facilities are indispensible for modern neuroscience.
With the existing strength, the further establishment of MIBR at PKU will provide the academic and physical center, nucleating our neuroscience research so far scattered around the main and medical campuses, and catapulting PKU to the international forefront of brain research.
PKU has always valued our friends dearly. As a testimony to our long memory of our friends, there stands a pavilion in the middle of our lake, paying tribute to Henry W. Luce, father of Henry R.Luce the publisher of Time, Life, Fortune and Sports Illustrated, who raised funds for our buildings in the 1920s. This is the only memorial pavilion named after a Westerner on the campus of a top Chinese university. The McGovern Institute will be a milestone in China-US cooperation in education and science. We have secured funds for the building to house the MIBR at PKU.
I enclose the formal Proposal for the McGovern Institute for Brain Research at Peking University. I look forward to working with you on this exciting project.
Sincerely,
Qifeng Zhou, Ph. D.
President, Peking University
Professor, Peking University School of Chemistry and Molecular Engineering
Member, Chinese Academy of Sciences
Enclosure: A Proposal for the McGovern Institute for Brain Research at Peking University
6） 附件三 2010年北京大学脑研究所提议(饶毅写)
A Proposal for the McGovern Institute for Brain Research
at Peking University
Summary
Because of its historical influence, its multidisciplinary strength in the neurosciences, and its firm commitment to support the new institute, Peking University (PKU) is the best possible Chinese host for a McGovern Institute for Brain Research (MIBR) in China. PKU has recently invested heavily in centers for optical imaging, MRI, chemical biology and molecular medicine whose expertise and facilities can be shared by MIBR. PKU runs the only internationally accredited primate center and the best academically oriented mental health hospital in China, further providing MIBR with opportunities for collaborations and for translation and clinical research. MIBR will be governed by a board of directors with representatives appointed by the McGoverns and PKU. PKU has secured funds for, and started designing, a new research building to house the institute. PKU will provide start-up funds and benefits to MIBR researchers. The McGoverns will provide ... PKU will not only make MIBR the core for integrating its research force in the neurosciences, but also support MIBR as a model for further reform of education and research at PKU in general: the autonomy of MIBR will be a key part of this commitment.
The Historical Impact of PKU and Its Successes in International Collaborations
Establishment of MIBR-Beijing at PKU will have long term impact that is unimaginable at other locations. PKU, through its leading roles in education and research, as well as the activities of its faculty and staff.
Our students and alumni have not only shaped Chinese education, but also influenced modern Chinese history to the extent unmatched by any other university in the country. PKU has been the most innovative university in China, pioneering new approaches in education and research.
The high regard of PKU by the general Chinese public will ensure that the impact MIBR at PKU will be felt beyond neuroscience.
PKU is uniquely poised to integrate different philosophies, pedagogies and approaches of the East with those of the West. PKU has been the most successful educational institution in integrating the traditional Chinese education and Western education. Part of PKU is the first national university of China. Part of it was Yenching University which was established and run for its first 2 decades by Americans including John Leighton Stuart as its president and Henry W. Luce as its vice president. No other institutions in China can be compared to the historical experience of PKU in efficiently integrating two major institutions with huge differences.
PKU has proven that it continues to lead the efforts in combining the best in the East with that from the West. In the past decade, it became the only Chinese university to host a Kavli institute in astronomy, funded by the Kavli foundation and operated by international standards.
（北大Kavli天文研究所）
In the last decade, both Yale and Stanford have also chosen PKU as their locations for Chinese campus. Thus, from the 1920s to the present, PKU is well experienced in international cooperation. PKU is ready to host the McGovern Institute in Brain Research.
PKU Environment
PKU is strong in science, humanities and medicine. This provides a cultural environment for interactions and enrichment, which does not exist in institutions lacking strength in liberal arts and humanities.
The physical environment of PKU is regarded as the most beautiful in Beijing.
Shown above is a painting of the original village on this site by a famous artist in 1617.
Shown below is a current picture: the pagoda will be visible from the MIBR building under design.
Life Sciences at PKU
PKU has an excellent tradition in the life sciences. One of its presidents, Yan Fu严复, was the first person to introduce evolution into China in the late 1800s when he translated Thomas Huxley into Chinese. The intellectual heritage of the American geneticist Thomas H. Morgan is highly visible and long lasting at PKU. Three of his early graduate students, including Alice Boring 博爱礼and JC Li 李汝祺who worked here for more than 30 and 50 years on this campus, respectively, shaped the teaching of biology and genetics in China. The intellectual lineage of several current faculty members can be traced to Morgan.
In 1948, the PKU press published an English textbook on population genetics by our faculty member CC Li李景均, which was widely used in the US for the next 20 years, an accomplishment unimaginable at any Chinese universities for many decades.
Currently, research in the life sciences at PKU range from the atomic, molecular and cellular, to the population levels. Among our exciting findings were treatment of diabetes in mice by stem cells, highly efficient induction of human pluripotent cells, identification of compounds inhibiting tumors, improvement of cotton quality by molecular biology.
Neuroscience at PKU
The overall strength of PKU in brain research is unparalleled in China. There are more than 80 laboratories working full time on neuroscience, more than any institution in China. PKU is the only Chinese institution with researchers ranging from cognitive, computational, systems, to cellular and molecular neuroscience, currently distributed in multiple departments: from psychology, linguistics, computer science, biomedical engineering, biology, physiology, medicine, neurology to psychiatry. PKU researchers study human beings in health and sickness, as well as animal models.
Among our findings are genes crucial for social interactions in insects and mammals, social trust and cognition in humans, modern and traditional treatment of pain, new optical probes for free radicals that open a new avenue for studying neurodegeneration, genetic susceptibilities to schizophrenia and autism,….
Neuroscience is well supported at PKU, not only from sources inside PKU but also from the outside.
PKU faculty members publish the standard neuroscience textbook educating several generations of Chinese neuroscientists.
PKU is rapidly expanding it neuroscience. PKU is the only Chinese institution which has recruited neuroscientists with tenured positions in the West to return to work full time in China, changing the situation that most recruitments in the past have been limited to the junior level. This proves the attraction of PKU for neuroscientists, which bodes well for prospective MIBR recruitment.
Facilities for Neuroscience Research at PKU
In addition to facilities available at other institutions in China, PKU has facilities for neuroscience research that far surpass other Chinese institutions. In fact, some of our facilities do not exist elsewhere.
PKU is the only Chinese university with a primate center accredited internationally (by the AAALAC). This provides a high quality facility for primate research, which is essential for brain research at MIBR.
PKU has a psychiatry hospital which not only provides excellent service to patients, but is also the leader in psychiatry research in China, using modern genetic and molecular approaches to study the etiology of psychiatric diseases. Among its research was whole genome association study of schizophrenia and linkage of genetic susceptibility of schizophrenia to neuroimaging.
PKU has established a Center for Imaging of Biological Molecules, headed by the Harvard professor Sunney Xiaoliang Xie, a pioneer of single molecular imaging. The substantial investment of PKU in the Imaging Center provides strong technical support to the prospective McGovern Institute because the Imaging Center will not only use state of the art imaging facilities, but also develop the best imaging technology and equipment to the demand of biologists such as those at MIBR.
We have also established a Biomedical Imaging Center in our physics department. It is headed by Jiahong Gao, formerly a professor at the University of Chicago. The newly purchased MRI at this center can serve cognitive neuroscientists at the MIBR.
PKU has established the first chemical biology department in the country, which actively collaborates with biomedical scientists to screen chemicals of biomedical significance. Among its lead compounds are those for treating brain tumor and regulating angiogenesis. One of our chemical biologist was a major figure in the first team of scientists to succeed in total synthesis of taxol, the anti-cancer drug, a milestone in organic chemistry. Our chemical biology department can also develop and provide probes for brain imaging.
PKU Support of MIBR
MIBR will be the core for neuroscience at PKU. It will serve as a magnet not only for attracting new recruits, but also a nucleating seed for the labs scattering around the PKU in more than 8 departments/institutes/schools.
PKU appreciates the opportunity to host a McGovern Institute and will do everything in its power to make MIBR a success in its research, education, and in its leading role of reforming Chinese education and science.
MIBR at PKU will aim to be an internationally leading institute. PKU will cooperate with the McGoverns and MIBR at MIT to establish an operating mechanism that allows the scientists to work collegially and efficiently.
PKU will support the autonomy of MIBR. On the board of directors of MIBR, there will be representatives appointed by PKU and the McGoverns.
PKU will provide generous start-up packages, child care and education, and other benefits for its researchers......
PKU will provide a new building for PIs recruited by MIBR who will form a core of neuroscientists surrounded by some of the labs that are currently scattered around the campus. PKU will encourage MIBR members to interact with other neuroscientists in Beijing, in China and in the world.
New Building to House the McGovern Institute
It will have a Chinese style exterior and a Western style interior.
Representative Publications by Neuroscientists at Peking University
Biology
1. Zhou C, Rao Y, and Rao Y (2008). A subset of octopaminergic neurons are important for Drosophila aggression. Nature Neurosci 11:1059-1061.
2. Li X, Gao X, Liu G, Xiong W, Wu J, and Rao Y (2008). Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nature Neurosci 11:28-35.
3. Jiang H, Guo W, Liang XH, and Y Rao (2005). Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3b and its upstream regulators. Cell120:123-135.
4. Liu G, Beggs H, Jürgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu JY, and Rao Y (2004). Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons. Nature Neurosci 7:1222-1232.
5. Ward ME, Wu JY and Rao Y (2004). Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci USA 101:970-974.
6. Ward M, McCann C, DeWulf M, Wu JY and Rao Y (2003). Distinguishing between directional guidance and motility regulation in neuronal migration. J Neurosci 23:5170-5177.
7. Zhu Y, Yu T, Zhang X-C, Nagasawa T, Wu JY, and Rao Y (2002). Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nature Neurosci. 5:719-720.
8. Wong K, Ren X-R, Huang Y-Z, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong W-C, and Rao Y (2001). Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway. Cell 107:209-221.
9. Wu JY, Feng L, Park H-T, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Z, Zhang X-C, and Rao Y (2001). The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410:948-952.
10. Chen J, Wen L, Dupuis S, Wu JY, and Rao Y (2001). The N-terminal leucine rich regions in Slitare sufficient to repel olfactory bulb axons and subventricular zone neurons. J. Neurosci. 21:1548-1556.
11. Zhu Y, Li HS, Zhou L, Wu JY, and Rao Y (1999). Cellular and molecular guidance of GABAergic neuronal migration from an extra-cortical origin to the neocortex. Neuron 23: 473-485.
12. Wu W, Wong K, Chen JH, Jiang ZH, Dupuis S, Wu JY, and Rao Y (1999). Directional guidance of neuronal migration in the olfactory system by the secreted protein Slit. Nature 400:331-336.
13. Li HS, Chen JH, Wu W, Fagaly T, Yuan WL, Zhou L, Dupuis S, Jiang Z, Nash W, Gick C, Ornitz D, Wu JY, and Rao Y (1999). Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons. Cell 96:807-818.
14. Li HS, Tierney C, Wen L, Wu JY and Rao Y (1997). A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm. Development 124:603-615.
15. Wu JY, Wen L, Zhang, WJ and Rao Y (1996). The secreted product of Xenopus lunatic fringe, a vertebrate signaling molecule. Science 273:355-358.
Institute of Molecular Medicine
1. Chaoliang Wei, Xianhua Wang, Min Chen, Kunfu Ouyang, Long-Sheng Song and Heping Cheng (2009) Calcium Flickers Steer Cell Migration. Nature 457:901-905.
2. Wang Wang, Huaqiang Fang, Linda Groom, Aiwu Cheng, Wanrui Zhang, Jie Liu, Xianhua Wang, Kaitao Li, Peidong Han, Ming Zheng, Jinhu Yin, Weidong Wang, Mark P. Mattson, Joseph P.Y. Kao, Edward G. Lakatta, Shey-Shing Sheu, Kunfu Ouyang, Ju Chen, Robert T. Dirksen, and Heping Cheng (2008). Superoxide Flashes in Single Mitochondria. Cell 134, 279-290.
3. Ouyang, k., Zheng, H., Qin, X., Zhang, C., Yang, D., Wang, X., Wu, C., Zhou Z., and Cheng, H (2005). Ca2+ sparks and secretion in dorsal root ganglion neurons. Proc. Natl. Acad. Sci. USA.102: 12259-12264.
4. Chen,X.K.,Wang, L.C., Zhou,Y., Cai, Q., Prakriya, M., Duan, K.L.,Sheng, Z.H., Lingle, C., and Zhou Z (2005). Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC. Nature Neurosci 8:1160 - 1168.
5. Chen X.K., Wang L.C., Zhou Y., Zheng L.H., and Zhou Z (2005) .'Kiss-and-run' glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes. J. Neurosci. 25:9236 –9243
6. Yang, H.,Zhang, C., Zheng, H., Xiong, W., Zhou, Z., Xu, T., and Ding, J.P. (2005). A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons. Eur. Biophy. J 34:1007-1016.
7. Wang, L.C., Xiong, W., Zheng, J., Zhou, Y., Zheng, H., Zhang, C., Zheng, L.H., Zhu, X.L., Xiong, Z.Q., Cheng, H., Wang, L.Y., and Zhou, Z (2006) The timing of endocytosis after activation of a G-protein-coupled receptor in a sensory neuron. Biophys J 90(10):3590-3598.
8. Yao, L.J., Wang, G., Ouyang, K.F., Wei, C.L., Wang, X.H., Wang, S.R., Yao, W., Huang, H.P., Luo, J.H., Wu, C.H., Liu, J., Zhou, Z., and Cheng, H (2006) Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons. Acta Pharmacologica Sinica 27: 848–852.
9. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Chen XW, Zhang B, Xiong W, Wang LY, Zheng LH, Landry M, Hokfelt T, Xu ZQD and Zhou Z (2007) Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc. Natl. Acad. Sci. USA.104:1401-1406.
10. Wuxue Zhang, Yong Zhang, Hui Zheng, Chen Zhang, Wei Xiong, John G. Olyarchuk, Michael Walker, Weifeng Xu, Min Zhao, Shuqi Zhao, Zhuan Zhou, Liping Wei (2007). SynDB: A Synapse protein DataBase based on Synapse Ontology. Nucl. Acid Res 35: D737–D741.
11. Xiao-Wei Chen, Yu Mu, Hong-Ping Huang, Ning Guo, Bo Zhang, Shuang-Yi Fan, Jia-Xiang Xiong, Shi-Rong Wang, Wei Xiong, Wei Huang, Tao Liu, Liang-Hong Zheng, Claire Xi Zhang, Li-Huan Li, Zheng-Ping Yu, Zhi-An Hu, Zhuan Zhou (2008). Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus coeruleus neurons. J. Neurosci. 28:3202-08.
12. Xiao-wei Chen, Wei Huang, Jun-an Yan, Hong-xiao Fan, Ning Guo, Jing Lü, Yun Xiu, Jing-li Gu, Claire Xi Zhang, Huai-zhen Ruan, Zhi-an Hu, Zheng-ping Yu, Zhuan Zhou (2008). Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells. Neurosci Lett 436:181-184.
13. Xiao-Wei Chen, Ya-Qin Feng, Chan-Juan Hao, Xiao-Li Guo, Xin He, Zhi-Yong Zhou, Ning Guo, Hong-Ping Huang, Wei Xiong, Hui Zheng, Pan-Li Zuo, Claire Xi Zhang, Wei Li and Zhuan Zhou (2008) DTNBP1,a schizophrenia susceptiblity gene, affects kinetics of transmitter release. J Cell Biol 181:791-801.
14. Hui Zheng, Wei Xiong, Chen Zhang, Xiao-Bing Wang, Tao Liu, Hong-Ju Liu, Lei Sun, Ye-Shi Wang, Liang-Hong Zheng, Claire Xi Zhang, and Zhuan Zhou (2009). Action potential patterns determine differential contributions of Ca2+-dependent and Ca2+-independent secretion in a sensory neuron. Biophys J. 96 :2449–2456.
15. Ying Zhang, Ping Su, Ping Liang, Tao Liu, Xu Liu, Xin-Ying Liu, Bo Zhang, Tao Han, Yan-Bing Zhu, Dong-Min Yin, Jun-Fa Li, Zhuan Zhou, Ke-Wei Wang and Yun Wang (2010) The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit. J Neurosci, in press.
PKU Psychiatric Hospital
1. Guan L, Wang B, Chen Y, Yang L, Li J, Qian Q, Wang Z, Faraone SV, Wang Y. (2009). A high-density single-nucleotide polymorphism screen of 23 candidate genes in attention deficit hyperactivity disorder: suggesting multiple susceptibility genes among Chinese Han population.Mol Psychiatry 14:546-54.
2. Huang Y, Kotov R, de Girolamo G, Preti A, Angermeyer M, Benjet C, Demyttenaere K, de Graaf R, Gureje O, Karam AN, Lee S, Lépine JP, Matschinger H, Posada-Villa J, Suliman S, Vilagut G, Kessler RC. (2009). DSM-IV personality disorders in the WHO World Mental Health Surveys. Br J Psychiatry 195:46-53.
3. Yan H, Zuo XN, Wang D, Wang J, Zhu C, Milham MP, Zhang D, Zang Y. (2009). Hemispheric asymmetry in cognitive division of anterior cingulate cortex: A resting-state functional connectivity study. Neuroimage 47:1579-89.
4. Zhang H, Ding J, Tian W, Wang L, Huang L, Ruan Y, Lu T, Sha Y, Zhang D. (2009). Ganglioside GM1 binding the N-terminus of amyloid precursor protein. Neurobiol Aging 30:1245-53.
5. Wang XD, Su YA, Guo CM, Yang Y, Si TM. (2008). Chronic antipsychotic drug administration alters the expression of neuregulin 1beta, ErbB2, ErbB3, and ErbB4 in the rat prefrontal cortex and hippocampus. Int J Neuropsychopharmacol. 11:553-61.
6. Qu M, Tang F, Yue W, Ruan Y, Lu T, Liu Z, Zhang H, Han Y, Zhang D, Wang F, Zhang D. (2007).Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population. Am J Med Genet B Neuropsychiatr Genet. 144:266-70.
7. Wu S, Yue W, Jia M, Ruan Y, Lu T, Gong X, Shuang M, Liu J, Yang X, Zhang D.(2007). Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. Am J Med Genet B Neuropsychiatr Genet. 144:266-70.
8. Zhang XY, Tan YL, Cao LY, Wu GY, Xu Q, Shen Y, Zhou DF. (2006). Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics. Schizophr Res 81:291-300.
9. Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, Gong X, Zhang Y, Yang X, Zhang D. (2005). Positive association of the OXTR gene with autism in the Chinese Han Population. Biol Psychiatry58:74-7.
10. Zhang XY, Zhou DF, Cao LY, Wu GY, Shen YC. (2005). Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics. Neuropsychopharmacology 30:1532-8.
11. Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY, Shen YC.(2005). Prolactin levels in male schizophrenic patients treated with risperidone and haloperidol: a double-blind and randomized study. Psychopharmacology 178:35-40.
12. Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY, Shen YC.(2004). Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia. J Clin Psychiatry 65:940-7.
13. Zha Q, Ruan Y, Hartmann T, Beyreuther K, Zhang D. (2004). GM1 ganglioside regulates the proteolysis of amyloid precursor protein Mol Psychiatry 9: 946-52.
14. Wang F., Sun Z.G., Cui L.W., Du X.K., Hong N., Zhang D.(2004). Anterior cingulum abnormalities in male schizophrenia with diffusion tensor imaging. Am. J. Psychiatry 161: 573-5.
15. Yang J, Si T, Ling Y, Ruan Y, Han Y, Wang X, Zhang H, Kong Q, Li X, Liu C, Zhang D, Zhou M, Yu Y, Liu S, Shu L, Ma D, Wei J, Zhang D. (2003). Association Study of the Human FZD3 Locus with Schizophrenia. Biol Psychiatry 54: 1298-301.
16. Yang J, Si T, Ruan Y, Ling Y, Han Y, Wang X, Zhou M, Zhang H, Kong Q, Liu C, Zhang D, Yu Y, Liu S, Ju G, Shu L, Ma D, Zhang D. (2003). Association study of neuregulin 1 gene with schizophrenia. Mol Psychiatry 8: 706-9.
17. Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY, Shen YC.(2003). The effect of risperidone treatment on superoxide dismutase in schizophrenia. J Clin Psychopharmacol. 23:128-31.
18. Zhang XY, Zhou DF, Zhang PY, Wu GY, Cao LY, Shen YC.(2002). Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophr Res. 57:247-58.
19. Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY, Shen YC. (2001). Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study. Int Clin Psychopharmacol 16:325-30.
20. Wang X, Gao L, Shinfuku N, Zhang H, Zhao C, Shen Y. (2000）Longitudinal study of earthquakeb related PTSD in a randomly selected community sample in north China. Am J Psychiatry 157(8):1260-6.
Neuroscience Institute at PKU Health Sciences Center
1. Han JS, Xie CW (1982). Dynorphin: potent analgesic effect in spinal cord of the rat. Life Sci31:1781-4.
2. Han JS, Terenius L (1982). Neurochemical basis of acupuncture analgesia. Annu Rev Pharmacol Toxicol 22:193-220.
3. Han JS, Ding XZ, Fan SG (1986). Cholecystokinin octapeptide (CCK-8): antagonism to electroacupuncture analgesia and a possible role in electroacupuncture tolerance. Pain 27:101-15.
4. Tian JH, Xu W, Fang Y, Mogil JS, Grisel JE, Grandy DK, Han JS (1997). Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. Br J Pharmacol 120:676-80.
5. Wang Y, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM (2004). Interaction between protein kinase C mu and the vanilloid receptor type 1. J Biol Chem 279:53674-82.
6. Chen XQ, Fung YWW, Yu ACH (2005). Association of 14-3-3 gamma and phosphorylated bad attenuates injury in ischemic astrocytes. J Cerebr Blood F Met 25:338-47.
7. Chen XQ, Qin LY, Zhang CG, Yang LT, Gao Z, Liu S, Lau LT, Fung YWW, Greenberg DA, Yu ACH (2005). Presence of Neuroglobin in Cultured Astrocytes. Glia 50:182-6.
8. Yang YR, He Y, Zhang Y, Li Y, Li YF, Han Y, Zhu HH, Wang Y (2007). Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain 127:109-20.
9. He Y, Li HL, Xie WY, Yang CZ, Yu ACH, Wang Y (2007). The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte. Glia 55:573-83.
10. Ma YY, Chu NN, Guo CY, Han JS, Cui CL (2007). NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. Exp Neurol 203:309-19.
11. Wang HY, Yan Y, Liu Q, Huang YH, Shen Y, Chen LJ, Chen Y, Yang QY, Hao Q, Wang KW, Chai JJ. (2007). Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat Neurosci 10:32-9.
12. Yin DM, Huang YH, Zhu YB, Wang Y (2008). Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus. J Neurosci28:8832-43.
13. Jiang YQ, Xing GG, Wang SL, Tu HY, Chi YN, Li J, Liu FY, Han JS, Wan Y (2008). Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain 137:495-506.
14. Zhu HH, Yang YR, Zhang H, Han Y, Li YF, Zhang Y, Yin DM, He QH, Zhao ZQ, Blumberg PM, Han JS, Wang Y (2008). Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity. Pain 137:574-88.
15. Xie WY, He Y, Yang YR, Li YF, Kang K, Xing BM, Wang Y (2009). Disruption of Cdk5-Associated Phosphorylation of Residue Threonine-161 of the delta-Opioid Receptor: Impaired Receptor Function and Attenuated Morphine Antinociceptive Tolerance. J Neurosci 29:3551-64.
16. Wang N, Wang JY, Luo F (2009). Corticofugal outputs facilitate acute, but inhibit chronic pain in rats. Pain 142:108-15.
17. Liang P, Wang HY, Chen H, Cui YY, Gu LC, Chai JJ, Wang KW (2009). Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. J Biol Chem 284:4960-7.
18. Hu L, Chu NN, Sun LL, Zhang R, Han JS, Cui CL (2009). Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area. Addict Biol 14:431-7.
19. Li M, Sun M, Liu Y, Yu J, Yang H, Fan DS, Dehua Chui (2010). Copper down-regulates neprilysin activity through modulation of neprilysin degradation. J Alzheimer's Dis 19:161-9.
20. Yu J, Sun M, Chen Z, Lu JY, Liu Y, Zhou L, Fan DS, Xue XM, Chui DH (2010). Magnesium modulates Amyloid-beta precursor protein trafficking and processing. J Alzheimer's Dis (in press).
PKU Psychology Department
1. Xu, X., Zuo, X., Wang, X., Han, S. (2009). Do you feel my pain? Racial group membership modulates empathic neural responses. J Neurosci 29:8525-8529.
2. Han, S., Northoff, G. (2008). Culture-sensitive neural substrates of human cognition: A transcultural neuroimaging approach. Nature Rev Neurosci 9 :646-654.
3. Sui, J., Han, S. (2007). Self-construal priming modulates neural substrates of self-awareness. Psychol Sci 18 :861-866.
4. Han, S., Jiang, Y., Gu, H., Rao, H., Mao, L., Cui, Y., Zhai, R. (2004). The role of human parietal cortex in attention networks. Brain 127: 650-659.
5. Bi T., Cai P., Zhou T. and Fang F (2009). The effect of crowding on orientation-selective adaptation in human early visual cortex. J Vision 9:13:1-10
6. Ye, Z., & Zhou, X. (2009). Executive control in language processing. Neurosci Biobeh Rev33:1168-1177.
7. Ye, Z., & Zhou, X. (2009). Conflict control during sentence comprehension: fMRI evidence. Neuroimage 48:280-290.
8. Zhang, D., Zhou, X., & Martens, S. (2009). The impact of negative attentional set upon target processing in RSVP: An ERP study. Neuropsychologia 47:2604-2614.
9. Yu, R., & Zhou, X. (2009). To bet or not to bet? The error negativity or error-related negativity associated with risk taking choices. J Cog Neurosci 21:684–696.
10. Du, Y., Ma, T.-F., Wang, Q., Wu, X.-H., Li, L. (2009). Two crossed axonal projections contribute to binaural unmasking of frequency-following responses in rat inferior colliculus. Eur J Neurosci30:1779-1789.
11. Du, Y., Huang, Q., Wu, X.-H., Galbraith, G.C., Li, L. (2009). Binaural unmasking of frequency-following responses in rat amygdala. J Neurophysiol 101:1647-1659.
12. Liao, J and Wang, L (2009). Face as a Mediator of the Relationship between Material Value and Brand Consciousness. Psychology Marketing 26:987-1001.
(北大脑研究所少部分学生加入老师十年第一次合影）