摄入多酚类化合物能降低胃癌风险？ | 热心肠日报
[IF:6.126]
Polyphenol Intake and Gastric Cancer Risk: Findings from the Stomach Cancer Pooling Project (StoP)
多酚摄入与胃癌风险：来自胃癌库（StoP）项目的发现
10.3390/cancers12103064
10-20, Article
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Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54–0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55–0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56–0.92), flavanols (OR = 0.77, 95% CI = 0.66–0.88), flavanones (OR = 0.57, 95%CI = 0.44–0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55–0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57–0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51–1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58–1.06). Further investigations from longitudinal data are needed to confirm this association.
First Authors:
Facundo Vitelli-Storelli
Correspondence Authors:
Jesus Vioque
All Authors:
Facundo Vitelli-Storelli,Marta Rossi,Claudio Pelucchi,Matteo Rota,Domenico Palli,Monica Ferraroni,Nuno Lunet,Domenico Palli,Lizbeth López-Carrillo,David Georgievich Zaridze,Dmitry Maximovich,María Rubín García,Gemma Castaño-Vinyals,Nuria Aragonés,Manuela Garcia de la Hera,Raúl Ulises Hernández-Ramírez,Eva Negri,Rossella Bonzi,Mary H Ward,Areti Lagiou,Pagona Lagiou,Malaquías López-Cervantes,Paolo Boffetta,M Constanza Camargo,Maria Paula Curado,Zuo-Feng Zhang,Jesus Vioque,Carlo La Vecchia,Vicente Martín Sánchez