学术盛宴来袭！2020年ESMO最新公布LBA重磅研究，轻松提前看！
2020 年欧洲肿瘤内科学会(ESMO)年会将于9月19日-21日在线上虚拟召开。作为肿瘤领域一年一度的学术盛宴，重磅研究必不可少，其中LBA系列最为神秘，堪称重磅中的典范。2020ESMO，截至目前公布的LBA研究都有哪些？下面跟随小编一起来看一看吧~
主席研讨会
LBA1 - Osimertinib adjuvant therapy inpatients (pts) with early stage EGFR mutated (EGFRm) NSCLC after tumourresection (ADAURA): sites of disease recurrence
早期EGFR突变NSCLC患者肿瘤切除术后接受奥希替尼辅助治疗(ADAURA)：疾病复发部位
LBA2 - Lorlatinib vs Crizotinib in the First-line Treatment of Patients (pts) with Advanced ALK-Positive Non-SmallCell Lung Cancer (NSCLC): Results of the Phase 3 CROWN Study
劳拉替尼对比克唑替尼一线治疗晚期ALK阳性非小细胞肺癌(NSCLC)：III期CROWN研究结果
LBA3 - An international randomized trial,comparing post-operative conformal radiotherapy (PORT) to no PORT, in patientswith completely resected non-small cell lung cancer (NSCLC) and mediastinal N2involvement. Primary end-point analysis of Lung ART (IFCT-0503, UK NCRI, SAKK)NCT00410683.
一项在完全切除且伴有纵隔N2受累的非小细胞肺癌(NSCLC)患者中比较术后放疗(PORT)与无PORT的国际随机化试验：Lung ART研究的主要终点分析
LBA4 - IPATential150: Phase III study ofipatasertib (ipat) plus abiraterone (abi vs placebo (pbo) plus abi inmetastatic castration-resistant prostate cancer (mCRPC)
IPATential150：在转移性去势抵抗性前列腺癌(mCRPC)患者中比较ipatasertib+阿比特龙与安慰剂+阿比特龙的III期研究
LBA5 - Abemaciclib in high risk earlybreast cancer
阿贝西利在高风险早期乳腺癌中的应用
LBA6 - Nivolumab (NIVO) Plus Chemotherapy(Chemo) Versus Chemo as First-Line (1L) Treatment for Advanced GastricCancer/Gastroesophageal Junction Cancer (GC/GEJC)/Esophageal Adenocarcinoma(EAC): First Results of the CheckMate 649 Study
纳武利尤单抗联合化疗对比单药化疗一线治疗晚期胃癌/胃食管交界处癌(GC/GEJC)/食管腺癌(EAC)：CheckMate649研究的首次结果
LBA7 - Nivolumab plus chemotherapy versus chemotherapy alone in patient with previously untreated advanced or recurrentgastric/gastroesophageal junction (G/GEJ) cancer: ATTRACTION-4 (ONO-4538-37)study
纳武利尤单抗联合化疗对比单药化疗在既往未经治疗的晚期或复发性胃/胃食管交界处癌(G/GEJ)患者：ATTRACTION-4(ONO-4538-37)研究
LBA8 - Pembrolizumab Plus Chemotherapy Versus Chemotherapy as First-Line Therapy in Patients With Advanced EsophagealCancer: The Phase 3 KEYNOTE-590 Study
帕博利珠单抗联合化疗对比化疗作为晚期食管癌患者的一线治疗：KEYNOTE-590 III期研究
LBA9 - Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer (EC/GEJC) Following Neoadjuvant Chemoradiation Therapy (CRT): First Results of the CheckMate 577Study
新辅助放化疗(CRT)后使用纳武利尤单抗辅助治疗食管或胃食管连接部癌(EC/GEJC)术后患者：CheckMate 577研究的首次结果
肺癌
LBA50 - ACTIVE: Apatinib plus gefitinib versus placebo plus gefitinib as first-line treatment for advanced epidermalgrowth factor receptor-mutant (EGFRm) non-small-cell lung cancer (NSCLC): amulticentered, randomized, double-blind, placebo-controlled phase III trial(CTONG1706)
ACTIVE：阿帕替尼联合吉非替尼对比安慰剂加吉非替尼作为晚期表皮生长因子受体突变(EGFRm)非小细胞肺癌(NSCLC)的一线治疗：一项多中心、随机、双盲、安慰剂对照的III期试验(CTONG1706)
LBA51 - KEYNOTE-024 5-year OS update:first-line (1L) pembrolizumab (pembro) vs platinum-based chemotherapy (chemo)in patients (pts) with metastatic NSCLC and PD-L1 tumor proportion score (TPS) ≥50%
KEYNOTE-024 5年OS更新：帕博利珠单抗对比铂类基础化疗一线治疗PD-L1肿瘤比例评分(TPS)≥50%的转移性NSCLC患者
LBA52 - EMPOWER-Lung 1: Phase 3 first-line (1L) cemiplimab monotherapy vs platinum-doublet chemotherapy (chemo)in advanced non-small cell lung cancer (NSCLC) with programmed celldeath-ligand 1 (PD-L1) ≥50%
EMPOWER-Lung 1: 西米普利单抗单药对比铂类双药化疗一线治疗PD-L1≥50%的晚期非小细胞肺癌(NSCLC)患者的III期研究
LBA53 - Precision Immuno-Oncology for advanced Non-Small Cell Lung Cancer (NSCLC) patients (pts) treated with PD1/L1 immune checkpoint inhibitors(ICIs): a first analysis of the PIONeeR Study
接受PD1/L1免疫检查点抑制剂治疗的晚期非小细胞肺癌(NSCLC)患者的精准免疫肿瘤学：PIONeeR研究的首次分析
LBA54 - Randomized phase III trial of nivolumab in combination with carboplatin, paclitaxel, and bevacizumab asfirst-line treatment for patients with advanced or recurrent non-squamous NSCLC
纳武利尤单抗联合卡铂、紫杉醇和贝伐珠单抗作为晚期或复发性非鳞状NSCLC患者一线治疗的随机化III期试验
LBA55 - WJOG @Be Study: A Phase II Study of Atezolizumab (Atez) With Bevacizumab (Bev) for Non-Squamous (Sq)Non-Small-Cell Lung Cancer (NSCLC) with High PD-L1 Expression
LBA55-WJOG@Be研究：一项阿替利珠单抗联合贝伐珠单抗治疗PD-L1高表达的非鳞状非小细胞肺癌(NSCLC)的II期研究
LBA84 - Consolidation ipilimumab and nivolumab vs observation in limited stage SCLC after chemo-radiotherapy – results from the ETOP/IFCT 4-12 STIMULI trial
伊匹木单抗联合纳武利尤单抗巩固治疗对比安慰剂用于接受放化疗后的局限期SCLC——ETOP/IFCT 4-12 STIMULI试验的结果
早期乳腺癌
LBA11 - IMpassion031: results from a Phase 3 study of neoadjuvant (neoadj) atezolizumab + chemotherapy in early triple-negative breast cancer (TNBC)
IMpassion031：阿替利珠单抗联合化疗新辅助治疗早期三阴性乳腺癌(TNBC)的III期研究结果
LBA12 - PALLAS: A randomized phase III trial of adjuvant palbociclib with endocrine therapy versus endocrine therapy alone for HR+/HER2- early breast cancer
PALLAS：哌柏西利联合内分泌治疗对比单独内分泌治疗用于HR +/HER2-早期乳腺癌辅助治疗的随机III期试验
转移性乳腺癌
LBA16 - IMpassion130: final OS analysis from the pivotal Phase III study of atezolizumab + nab-paclitaxel vs placebo +nab-paclitaxel in previously untreated locally advanced or metastatictriple-negative breast cancer
IMpassion130：阿替利珠单抗 + 白蛋白结合型紫杉醇对比安慰剂 + 白蛋白结合型紫杉醇治疗既往未经治疗的局部晚期或转移性三阴性乳腺癌患者的关键III期研究的最终OS分析
LBA17 - ASCENT: A randomized phase 3 study of sacituzumab govitecan (SG) vs treatment of physician’s choice (TPC) inpatients (pts) with previously treated metastatic triple-negative breast cancer(mTNBC)
ASCENT：一项在经治转移性三阴性乳腺癌(mTNBC)的患者中比较sacituzumab govitecan(SG)与医生选择治疗(TPC)的随机、III期研究
LBA18 - Overall Survival (OS) Results From SOLAR-1, a Phase 3 Study of Alpelisib (ALP) + Fulvestrant (FUL) for Hormone Receptor-Positive (HR+), Human Epidermal Growth Factor Receptor2-Negative (HER2–) Advanced Breast Cancer (ABC)
阿吡利塞(ALP)联合氟维司群(FUL)治疗HR +、HER2-晚期乳腺癌的III期研究SOLAR-1的总生存期(OS)结果
LBA19 - GEICAM/2014-12 (FLIPPER) study:First analysis from a randomized phase II trial of fulvestrant(F)/palbociclib (P) versus (vs.) F/placebo (PL) as first-line therapy inpostmenopausal women with HR (Hormone Receptor)+/HER2– endocrine sensitiveadvanced breast cancer (ABC)
GEICAM/2014-12(FLIPPER)研究：氟维司群/哌柏西利对比氟维司群/安慰剂一线治疗HR+/HER2-内分泌敏感型晚期乳腺癌（绝经后女性）的的随机II期试验的首次分析
泌尿生殖系统肿瘤
LBA23 - Pembrolizumab (P) combined with chemotherapy (C) vs C alone as first-line (1L) therapy for advanced urothelial carcinoma (UC): KEYNOTE-361
帕博利珠单抗联合化疗对比化疗单药作为晚期尿路上皮癌(UC)的一线治疗：KEYNOTE-361研究
LBA24 - TROPHY-U-01 Cohort 1 Final Results: A Phase 2 Study of Sacituzumab Govitecan (SG) in Metastatic Urothelial Cancer (mUC) That Has Progressed After Platinum (PLT) and Checkpoint Inhibitors(CPI)
TROPHY-U-01队列1最终结果：转移性尿路上皮癌(mUC)患者在铂类和免疫检查点抑制剂治疗进展后采用Sacituzumab Govitecan (SG)的II期研究
LBA25 - Results from the phase 2 BIOmarker driven trial with Nivolumab (N）andIpilimumab or VEGFR tyrosine Kinase inhibitor (TKI) in naïve metastatic Kidney cancer (m-ccRCC) patients (pts): the BIONIKK trial.
纳武利尤单抗联合伊匹木单抗或VEGFR酪氨酸激酶抑制剂(TKI)治疗初治转移性肾癌(m-ccRCC)患者的生物标志物驱动II期试验的结果：BIONIKK试验
妇科肿瘤
LBA28 - A randomised double-blind placebo-controlled phase II trial of palbociclib combined with letrozole (L) in patients (pts) with oestrogen receptor-positive advanced/recurrent endometrial cancer (EC): NSGO-PALEO /ENGOT-EN3 trial.
一项在雌激素受体阳性(ER +)晚期/复发性子宫内膜癌(EC)患者中进行的哌柏西利联合来曲唑(L)治疗的随机、双盲、安慰剂对照II期试验：NSGO-PALEO/ENGOT-EN3试验
LBA29 - Individualized Starting Dose of Niraparib in Chinese Patients with Platinum-Sensitive Recurrent Ovarian Cancer(PSROC): A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial (NORA)
在铂类药物敏感的中国复发性卵巢癌患者中探索尼拉帕利个体化起始剂量(PSROC)：一项随机、双盲、安慰剂对照、3期试验(NORA)
LBA30 - INOVATYON study: Randomized phase III international study comparing trabectedin/PLD followed by platinum atprogression vs carboplatin/PLD in patients with recurrent ovarian cancer progressing within 6-12 months after last platinum line.
INOVATYON研究：在末次铂类药物治疗后6-12个月内出现疾病进展的复发性卵巢癌患者中对比曲贝替定/脂质体阿霉素（PLD）+疾病进展后加用铂类与卡铂/PLD的随机化、III期、国际研究
LBA31 - Primary results from IMagyn050/GOG 3015/ENGOT-OV39, a double-blind placebo (pbo)-controlledrandomised phase 3 trial of bevacizumab (bev)-containing therapy +/-atezolizumab (atezo) for newly diagnosed stage III/IV ovarian cancer (OC)
IMagyn050/GOG 3015/ENGOT-OV39研究的主要结果：一项在新诊断的III/IV期卵巢癌(OC)患者中评价贝伐单抗+/-阿特珠单抗治疗的双盲、安慰剂对照、随机、III期试验
LBA32 - Tisotumab vedotin in previously treated recurrent or metastatic cervical cancer: results from the phase 2 innovaTV 204/GOG-3023/ENGOT-cx6 study
Tisotumab vedotin在既往接受过治疗的复发性或转移性宫颈癌中的应用：来自II期innovaTV 204/GOG-3023/ENGOT-cx6研究的结果
头颈部肿瘤
LBA38 - Pembrolizumab versus cetuximab,concomitant with radiotherapy (RT）inlocally advanced head and neck squamous cell carcinoma (LA-HNSCC): Results ofthe GORTEC 2015-01 “PembroRad”randomized trial
帕博利珠单抗对比西妥昔单抗联合放疗(RT)治疗局部晚期头颈部鳞状细胞癌(LA-HNSCC)：GORTEC 2015-01“PembroRad”随机试验结果
LBA39 - 3-years follow-up of double-blind randomized phase II comparing concurrent high-dose cisplatin chemo-radiationplus Debio-1143 (Xevinapant) or placebo in high-risk patients with locallyadvanced squamous cell carcinoma of the head and neck
在局部晚期头颈部鳞状细胞癌高风险患者中对比同步高剂量顺铂化放疗加Debio-1143(Xevinapant)或安慰剂的随机、双盲II期试验的3年随访结果
LBA40 - Neoadjuvant nivolumab and nivolumab plus ipilimumab induce (near） complete responses in patients with head and neck squamous cell carcinoma; the IMCISION trial.
IMCISION试验：纳武利尤单抗新辅助治疗和纳武利尤单抗联合伊匹木单抗治疗头颈部鳞状细胞癌患者可诱导（接近）完全缓解
探索性免疫疗法
LBA41 - LEAP-005: Phase 2 Study ofLenvatinib (Len) Plus Pembrolizumab (Pembro) in Patients (Pts) With Previously Treated Advanced Solid Tumors
乐伐替尼联合帕博利珠单抗治疗既往接受过治疗的晚期实体瘤患者的2期研究
黑色素瘤和其他皮肤肿瘤
LBA43 - Spartalizumab plus dabrafenib andtrametinib (Sparta-DabTram) in patients (pts) with previously untreated BRAFV600–mutant unresectable or metastatic melanoma: results from the randomized part 3 of the Phase III COMBI-i trial
Spartalizumab + 达拉非尼 +曲美替尼用于既往未经治疗的BRAF V600-突变不可切除或转移性黑色素瘤患者：III期COMBI-i试验随机分组第3部分的结果
LBA44 - Lenvatinib (len) plus pembrolizumab (pembro) for advanced melanoma(MEL) that progressed on a PD-1 orPD-L1 inhibitor: initial results of LEAP-00
乐伐替尼联合帕博利珠单抗用于PD-1或PD-L1抑制剂治疗后进展的晚期黑色素瘤(MEL)：LEAP-004的初步结果
LBA45 - First report of efficacy and safety from the phase II study SECOMBIT(SEquential COMBo Immuno and Targeted therapy study)
II期研究SECOMBIT(序贯联合免疫和靶向治疗)的首次疗效和安全性报告
LBA46 - Pembrolizumab versus placebo after complete resection of high-risk stage III melanoma: final resultsregarding distant metastasis-free survival from the EORTC 1325-MG/Keynote 054 double-blinded phase 3 trial
高危III期黑色素瘤完全切除后接受帕博利珠单抗对比安慰剂：EORTC 1325-MG/Keynote 054双盲III期试验无远处转移生存期的最终结果
胃肠消化道肿瘤
LBA65 - The Canadian Cancer Trials GroupPA.7 Trial: Results of a Randomized Phase II Study of Gemcitabine (GEM) andNab-Paclitaxel (Nab-P) vs. GEM, Nab-P, Durvalumab (D) and Tremelimumab (T) asFirst Line Therapy in Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)
加拿大癌症试验组PA.7试验：吉西他滨（GEM）+白蛋白结合型紫杉醇(Nab-P)对比GEM+Nab-P+度伐利尤单抗(D)和替西木单抗(T)一线治疗转移性胰腺导管腺癌(mPDAC)的随机、II期研究结果
公共政策
LBA66 - Disparities in access to oncology clinical trials in Europe in the period 2009-2019
2009-2019年间欧洲肿瘤学临床试验准入的差异
肉瘤
LBA67 - TRAMUNE, a phase Ib study combining Trabectedin and Durvalumab Results of the expansion cohort in patients with advanced pretreated Soft Tissue Sarcomas
TRAMUNE：曲贝替定联合度伐利尤单抗治疗晚期经治软组织肉瘤患者中的Ib期扩展队列研究结果
LBA68 - Results of the randomized,Placebo (PL)-controlled Phase II study evaluating the efficacy and safety of Regorafenib (REG) in patients (pts) with metastatic relapsed Ewing sarcoma(ES), on behalf of the French Sarcoma Group (FSG) and Unicancer
在转移性复发性尤文氏肉瘤(ES)患者中评价瑞戈非尼(REG)疗效和安全性的随机、安慰剂对照II期研究结果
SARS2-CoV-2与癌症
LBA69 - Impact of the COVID-19 pandemicon management of medical cancer treatments and psychological consequence forthe patients
COVID-19大流行对癌症药物治疗管理和患者心理预后的影响
LBA70 - The Impact of COVID-19 on Oncology Professionals: Initial Results of The ESMO Resilience Task ForceSurvey Collaboration
COVID-19对肿瘤专业人员的影响：ESMO Resilience Task Force Survey Collaboration调查的初步结果
LBA71 - Systemic cancer treatment-related outcomes in patients with SARS-CoV2 infection: A CCC19 registry analysis.
SARS-CoV-2感染患者的全身性癌症治疗相关结局：一项CCC19登记分析
LBA72 - Assessment of clinical and laboratory prognostic factors in patients with cancer and SARS-CoV-2 infection:The COVID-19 and Cancer Consortium(CCC19)
评估SARS-CoV-2感染癌症患者的临床和实验室预后因素：COVID-19和癌症联盟(CCC19)
LBA73 - The ORF1ab of SARS-CoV-2 encodesan immunodominant epitope restricted by HLA-A*01:01
SARS-CoV-2 ORF1ab编码免疫显性表位受HLA-A*01:01限制
LBA74 - Disparities in Cancer during the COVID-19 Pandemic: COVID-19 and Cancer Outcomes Study (CCOS)
COVID-19流行期间癌症的差异：COVID-19和癌症结局研究(CCOS)
LBA75 - Defining COVID-19 outcomes in thoracic cancer patients: TERAVOLT(Thoracic cancERs international coVid 19cOLlaboraTion)
定义胸部癌症患者的COVID-19结局：TERAVOLT
支持性和姑息治疗
LBA87 - A Pragmatic Cluster-Randomized Trial of Ambulatory Toxicity Management in Patients Receiving Adjuvant or Neo-adjuvant Chemotherapy for Early Stage Breast Cancer (AToM)
一项在接受辅助或新辅助化疗早期乳腺癌患者中进行动态毒性管理的集群随机试验
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