又又又一临床结果公布，亚精胺或可改善老年痴呆

又又又一临床结果公布，亚精胺或可改善老年痴呆，让患者有尊严地告别世界

【文献解读】

亚精胺的摄入对人类的记忆功能有益。近期，澳大利亚Reinhart教授团队发现，亚精胺治疗可以改善老年人的认知功能，并将其成果发布在NeuroImage杂志上。

该研究采用多中心双盲设计，在6个养老院中纳入85名老年人，随机分为两组，采用不同剂量的亚精胺摄入。通过记忆测试评估其认知功能，分为无痴呆、轻度痴呆、中度痴呆和重度痴呆四组，同时采集血样评估其血液中亚精胺的浓度。结果发现在无痴呆组亚精胺浓度与认知功能显著正相关，且轻中度痴呆的老年人在摄入高剂量亚精胺后认知水平明显改善。

作者表示，这些发现提示补充亚精胺在治疗老年痴呆症方面具有巨大的潜力，但仍需进一步研究亚精胺改善认知功能的特异性。

【文献节选】

Summary The worldwide prevalence of dementia is estimated at 35.6 million and will rise to 115 million by 2050. There is therefore an urgent need for well-founded dementia diagnostics and well-re- searched therapeutic options. Previous studies have highlighted that spermidine has the ability to trig- ger the important process of dissolving amyloid-beta plaques by autophagy. They also confirmed that nutritional intervention with the natural polyamine spermidine can prevent memory loss in aging model organisms. This multicentric double-blind preliminary study focused on the effect of oral spermidine supplementation on older adults’ cognitive performance. Memory tests were carried out on 85 subjects aged between 60 and 96 years in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration and measurement of metabolic parameters. The results demonstrated a clear correlation between the intake of spermidine and the improvement in cognitive performance in subjects with mild and moderate dementia in the group treated with the higher spermidine dosage. The most substantial improvement in test performance was found in the group of subjects with mild dementia with an increase of 2.23 points (p = 0.026) in the mini mental state examination (MMSE) and 1.99 (p = 0.47) in phonematic fluidity. By comparison, the group which had a lower spermidine intake showed consistent or declining cognitive performance.

【原文链接】

https://pubmed.ncbi.nlm.nih.gov/33211152/