右美托咪定与咪达唑仑用于牙种植术患者术中镇静效果的比较：一项随机临床试验
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Comparison in Sedative Effects between Dexmedetomidine and Midazolam in Dental Implantation: A Randomized Clinical Trial
背景与目的
右美托咪定是一种α2肾上腺素能受体激动剂，与其他药物相比它具有强效的镇静、镇痛和轻微呼吸抑制作用。本研究旨在比较咪达唑仑和右美托咪定用于牙种植术患者镇静的有效性和安全性。
方 法
将60名行牙种植术、ASA分级I或II级的患者随机分为咪达唑仑或右美托咪定镇静治疗组。记录患者术后镇痛持续时间、外科医生和患者满意度、清醒/镇静评分(OAAS)、疼痛视觉模拟评分(VAS)和生命体征。
结 果
右美托咪定组OAAS评分明显低于咪达唑仑组(p<0.05)，且镇痛持续时间明显长于咪达唑仑组，差异有统计学意义(p<0.05)。与咪达唑仑相比，更多的外科医生对使用右美托咪定的患者所达到的镇静/镇痛水平感到满意。
结 论
综上所述，右美托咪定的术后镇痛效果、外科医生满意度和镇静效果均优于咪达唑仑。
原始文献来源及摘要
Wang L, Zhou Y, Zhang T,et al. Comparison in Sedative Effects between Dexmedetomidine and Midazolam in Dental Implantation: A Randomized Clinical Trial [J]. Biomed Res Int. 2020. DOI:10.1155/2020/6130162
Abstract
AIM:Dexmedetomidine refers to an α2-adrenergic receptor agonist causing potent sedative, analgesic, and minimal respiratory depression compared with alternative drugs. The present study was aimed at comparing the efficaciousness and safety of midazolam and dexmedetomidine as sedatives for dental implantation.
Methods:We recruited 60 patients belonging to group I or II of the American Society of Anesthesiologists (ASA) and treated them with either midazolam or dexmedetomidine in a random manner. Patients’ duration of analgesia after surgery, surgeon and patient degrees of satisfaction, Observer’s Assessment of Alertness/Sedation Scale (OAAS) scores after drug administration, visual analogue scale (VAS) pain scores, and vital signs were recorded variables.
Results:Patients administered dexme etomidine had significantly lower OAAS scores than those administered midazolam (p < 0:05). Patients administrated dexmedetomidine had a significantly longer analgesia duration after the surgical procedure than those administered midazolam, and the difference was statistically significant (p < 0:05). Dexmedetomidine had a significantly larger number of surgeons satisfied with the level of sedation/analgesia than midazolam (p < 0:05).
Conclusions:Accordingly, it is considered that dexmedetomidine can achieve better postoperative analgesia, surgeon satisfaction, and sedation than midazolam.
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翻译：唐剑 编辑：冯玉蓉 审校：曹莹