FMT对溃疡性结肠炎的疗效能否长期持续？ | 热心肠日报

Gut

[IF:19.819]

Response to faecal microbiota transplantation in ulcerative colitis is not sustained long term following induction therapy

溃疡性结肠炎患者对粪菌移植的应答无法长期维持

10.1136/gutjnl-2020-323581

12-10, Other

Abstract & Authors:展开

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We read with interest the paper by Ng et al,1 which discussed the need to optimise faecal microbiota transplantation (FMT) processes in order to increase its therapeutic potential, especially in inflammatory bowel disease (IBD). While there is randomised controlled trial evidence that FMT can be effective in the induction of remission in patients with ulcerative colitis (UC),2–5 the durability of therapeutic response following FMT cessation is unknown. Furthermore, there is limited long-term safety data following FMT, especially in patients with IBD. In the FOCUS study, FMT delivered via an initial colonoscopy infusion, followed by enema therapy for 8 weeks was effective in mild to moderate UC remission induction.2 Here, we report the long-term outcomes from the FOCUS study.

First Authors:
Craig Haifer

Correspondence Authors:
Sudarshan Paramsothy

All Authors:
Craig Haifer,Aiasha Saikal,Ramesh Paramsothy,Nadeem O Kaakoush,Rupert W Leong,Thomas J Borody,Michael A Kamm,Sudarshan Paramsothy