菌群失调或可加速衰老？（综述） | 热心肠日报
Aging, Frailty, and the Microbiome: How Dysbiosis Influences Human Aging and Disease
衰老、衰弱与微生物组：失调如何影响人类衰老和疾病
10.1053/j.gastro.2020.09.060
12-07, Review
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The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that coexist in our bodies and are essential in protective, metabolic, and physiologic functions of human health. Gut dysbiosis has traditionally been linked to increased risk of infection but imbalances within the intestinal microbial community structure that correlate with untoward inflammatory responses are increasingly recognized as being involved in disease processes that affect many organ systems in the body. Furthermore, it is becoming more apparent that the connection between gut dysbiosis and age-related diseases may lie in how the gut microbiome communicates with both the intestinal mucosa and the systemic immune system, given that these networks have a common interconnection to frailty. We will therefore discuss recent advances in our understanding of the important role the microbiome plays in aging and how this knowledge opens the door for potential novel therapeutics aimed at shaping a less dysbiotic microbiome to prevent or treat age-related diseases.
First Authors:
John P Haran
Correspondence Authors:
John P Haran
All Authors:
John P Haran,Beth A McCormick