Skraup喹啉合成

苯胺，甘油，硫酸和氧化剂 (如PhNO2)反应制备喹啉的反应。

反应机理

甘油在酸性条件下先生成丙烯醛，苯胺对其进行共轭加成β-苯胺基丙醛，关环脱水得到二氢喹啉，氧化得到产物。

反应实例

参考文献

1. (a) Skraup, Z. H. Monatsh. Chem. 1880, 1, 316. Zdenko Hans Skraup (1850􀀐-1910) was born in Prague, Czechoslovakia. He apprenticed under Lieben at the University of Vienna. (b) Skraup, Z. H. Ber. 1880, 13, 2086.【Zdenko Hans Skraup (1850􀀐-1910)生于捷克斯洛伐克的布拉格。在维亚纳大学师从Lieben。】

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编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Skraup quinoline synthesis，page 562-563.