丁酸或有助于抵抗新冠肺炎 | 热心肠日报
Butyrate Regulates COVID-19–Relevant Genes in Gut Epithelial Organoids From Normotensive Rats
丁酸调节正常血压大鼠肠上皮类器官中COVID-19相关基因
10.1161/HYPERTENSIONAHA.120.16647
2020-12-02, Other
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It is increasingly evident that patients with hypertension are at high risk for coronavirus disease 2019 (COVID-19) and exhibit gastrointestinal symptoms suggesting that impaired gut-lung communications could be responsible, at least in part, for the multiorgan pathologies including cardiovascular manifestations of this disease.1 Higher expression of ACE2 (angiotensin-converting enzyme-2) and TMPRSS2 (transmembrane protease serine-2), key molecules in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection, in gut epithelium from spontaneously hypertensive rats supports this view.2 Finally, changes in gut microbiome associated with short-chain fatty acids, particularly butyrate, is found in both hypertension and COVID-19.1 Butyrate is an HDAC (histone deacetylase) inhibitor that maintains acetylation of histones, affecting chromatin organization and gene expression. Therefore, we sought to test the hypothesis that increased risk of COVID-19 in hypertension could, in part, be due to cumulative depletion of butyrate-producing gut bacteria leading to decreases in butyrate.1 Therefore, treatment with this short-chain fatty acid would regulate ACE2 and its partners influencing antiviral genes. This could be critical in the control of gut viral infection and rebalancing of the gut-lung axis.
First Authors:
Jing Li
Correspondence Authors:
Mohan K Raizada
All Authors:
Jing Li,Elaine M Richards,Eileen M Handberg,Carl J Pepine,Mohan K Raizada