医学影像英语每日读丨92.SCI论文摘要解读
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Alterations of mean diffusivity of pedunculopontine nucleus pathway in Parkinson's disease patients with freezing of gait.
Abstract
BACKGROUND:
Although freezing of gait (FOG) is a common and disabling symptom in Parkinson's disease (PD), the underlying mechanism of FOG has not been clearly elucidated. Using analysis of diffusion tensor imaging (DTI), we investigated anatomic structures associated with FOG in PD patients.
METHODS:
We enrolled 33 controls and 42 PD patients (19 patients with FOG and 23 without FOG). DTI data were compared between PD patients and controls, and also between PD patients with and without FOG. Whole brain voxel-based analysis and regions of interest analysis in the pedunculopontine nucleus were used for DTI analysis.
RESULTS:
Compared with normal controls, PD patients showed microstructural changes in various subcortical structures (substantia nigra, globus pallidum and thalamus), frontal and insula cortex. PD patients with FOG demonstrated altered mean diffusivities in subcortical structures connected with pedunculopontine nucleus, such as basal ganglia, thalamus and cerebellum in voxel-based analysis. Using region of interest analysis of pedunculopontine nucleus, fractional anisotropy values were reduced and mean diffusivity values were increased bilaterally in PD patients with FOG. In correlation analysis, the fractional anisotropy value of the right pedunculopontine nucleus was moderately correlated with the severity of FOG.
CONCLUSIONS:
Based on our results, microstructural changes of pedunculopontine nucleus and connected subcortical structures are closely related with FOG in PD patients.
帕金森病冻结步态患者脑桥神经核通路平均扩散速率的改变
摘要
背景：
尽管冻结步态（FOG）是帕金森病（PD）中常见的致残性症状，但FOG的潜在机制尚未明确阐明。我们采用扩散张量成像（DTI）分析来研究PD患者中与FOG相关的解剖结构。
方法：
我们招募了33名对照组和42名PD患者（19名为FOG的患者，23名患者无FOG）。比较PD患者和对照之间的DTI数据，以及FOG（+）与FOG（-）的PD患者之间的DTI数据。采用基于体素的全脑分析和感兴趣区分析对脑桥神经核进行DTI分析。
结果：
与正常对照组相比，PD患者在不同皮层下部位（黑质，苍白球和丘脑），额叶和岛叶皮质中显示出微结构改变。在基于体素的分析中，FOG（+）PD患者在与桥神经核连接的皮层下部位（例如基底神经节，丘脑和小脑）表现出平均扩散速率的改变。在感兴趣区分析中，FOG(+)PD患者脑桥神经核表现出其双侧各向异性分数值减少和平均扩散值增加。在相关分析中，右侧脑桥神经核的各向异性分数值与FOG的严重程度呈中等相关。
结论：
基于我们的结果，脑桥神经核和连接的皮层下结构的微观结构变化与PD患者的FOG密切相关。
来源：每天朗读一段医学影像学英语文章
圈主
深圳市人民医院放射科副主任医师杨敏洁