Chichibabin吡啶合成反应

醛和氨缩合制备吡啶的反应。

反应机理

反应实例

参考文献

1. Chichibabin, A. E. J. Russ. Phys. Chem. Soc. 1906, 37, 1229. Alexei E. Chichibabin (1871-􀀐1945) was born in Kuzemino, Russia. He was Markovnikov’s favorite student. Markovnikov’s successor, Zelinsky (of Hell–Volhard–Zelinsky reaction fame) did not want to cooperate with the pupil and gave Chichibabin a negative judgment on his Ph.D. work, earning Chichibabin the nickname “the self-educated man.”【 Alexei E. Chichibabin (1871-􀀐1945)生于俄国Kuzemino。他是Markovnikov最得意的弟子。Markovnikov的继任者Zelinsky（Hell–Volhard–Zelinsky反应以其名字命名）不愿意和学生一起工作，所以给Chichibabin的Ph.D.工作做了很消极的评价。也因此Chichibabin也得到了一个“自学成才”的绰号。】

2. Sprung, M. M. Chem. Rev. 1940, 40, 297-􀀐338. (Review).

3. Frank, R. L.; Riener, E. F. J. Am. Chem. Soc. 1950, 72, 4182-􀀐4183.

4. Weiss, M. J. Am. Chem. Soc. 1952, 74, 200􀀐-202.

5. Kessar, S. V.; Nadir, U. K.; Singh, M. Indian J. Chem. 1973, 11, 825􀀐-826.

编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Chichibabin pyridine synthesis，page 130-131.