Passerini反应

羧酸，C-异氰化合物和羰基化合物三组分缩合得到α-酰氧基酰胺的反应，此反应与 Ugi反应类似。

反应机理

反应实例

【J. Chem. Soc., Perkin Trans. 1 1979, 652-661】

【J. Prakt. Chem. 1997, 339, 385-389】

【Chem. Commun. 2000, 985–986】

【Org. Lett. 2001, 3, 3301–3304】

相关文献

1. Passerini, M. Gazz. Chim. Ital. 1921, 51, 126􀀐129. (b) Passerini, M. Gazz. Chim. Ital. 1921, 51, 181􀀐188. Mario Passerini (b, 1891) was born in Scandicci, Italy. He obtained his Ph.D. in chemistry and pharmacy at the University of Florence, where he was a professor for most of his career.

2. Ferosie, I. Aldrichimica Acta 1971, 4, 21. (Review).

3. Barrett, A. G. M.; Barton, D. H. R.; Falck, J. R.; Papaioannou, D.; Widdowson, D. A. J. Chem. Soc., Perkin Trans. 1 1979, 652􀀐661.

4. Ugi, I.; Lohberger, S.; Karl, R. In Comprehensive Organic Synthesis; Trost, B. M.; Fleming, I., Eds.; Pergamon: Oxford, 1991, Vol. 2, p.1083. (Review).

5. Bock, H.; Ugi, I. J. Prakt. Chem. 1997, 339, 385􀀐389.

6. Banfi, L.; Guanti, G.; Riva, R. Chem. Commun. 2000, 985–986.

7. Owens, T. D.; Semple, J. E. Org. Lett. 2001, 3, 3301–3304.

8. Xia, Q.; Ganem, B. Org. Lett. 2002, 4, 1631􀀐1634.

9. Banfi, L.; Riva, R. Org. React. 2005, 65, 1􀀐140. (Review).

10. Klein, J. C.; Williams, D. R. Passerini Reaction. In Name Reactions for Homologations-Part II; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2009, pp 765􀀐785. (Review).

11. Sato, K.; Ozu, T.; Takenaga, N. Tetrahedron Lett. 2013, 54, 661-664.

编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Passerini reaction，page 458-459.