去雄改变肠道菌群从而促进肥胖 | 热心肠日报

[IF:7.497]

Male castration increases adiposity via small intestinal microbial alterations

去雄通过改变小肠菌群促进肥胖

10.15252/embr.202050663

11-23, Article

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Castration of young males is widely used in the cattle industry to improve meat quality, but the mechanism linking hypogonadism and host metabolism is not clear. Here, we use metataxonomic and metabolomic approaches to evaluate the intestinal microbiota and host metabolism in male, castrated male (CtM), and female cattle. After pubescence, the CtM cattle harbor distinct ileal microbiota dominated by the family Peptostreptococcaceae and exhibit distinct serum and muscle amino acid profiles (i.e., highly abundant branched‐chain amino acids), with increased extra‐ and intramuscular fat storage. We also evaluate the causative factor(s) that underpin the alteration of the intestinal microbiota and host metabolic phenotype in response to hypogonadism. Castration of male mice phenocopies both the intestinal microbial alterations and obese‐prone metabolism observed in cattle. Antibiotic treatment and fecal microbiota transplantation experiments in a mouse model confirm that the intestinal microbial alterations associated with hypogonadism are a key contributor to the obese phenotype in the CtM animals. Collectively, targeting the gut microbiota is a potential therapeutic strategy for the treatment of both hypogonadism and obesity.

First Authors:
Tae Woong Whon

Correspondence Authors:
Jin‐Woo Bae

All Authors:
Tae Woong Whon,Hyun Sik Kim,Na‐Ri Shin,Eun Sung Jung,Euon Jung Tak,Hojun Sung,Mi‐Ja Jung,Yun‐Seok Jeong,Dong‐Wook Hyun,Pil Soo Kim,Yu Kyung Jang,Choong Hwan Lee,Jin‐Woo Bae

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