外科病理学实践:诊断过程的初学者指南 | 第12章 膀胱
Urothelial cells have increased nuclear size. A helpful hint is that the worst nuclei of CIS should be four to five times the size of lymphocyte nuclei (Figure 12.3).
尿路上皮细胞的核增大。一个有用的线索是,CIS最差的核应该是淋巴细胞核大小的4-5倍(图12.3)。
There are Hyperchromatic nuclei with irregular (“boulder-like”) outlines.
有不规则(“圆石状”)轮廓的深染核。
The urothelium has a tendency to fall apart, appearing denuded, with a few clinging cells.
尿路上皮有脱落的倾向,似乎裸露,有少量黏附的细胞。
Full-thickness involvement is not a requirement to diagnosis CIS (even scattered malignant cells with the above features justify a diagnosis of CIS).
诊断CIS并不必需全层受累(即使是散在的恶性细胞,只要具有上述特征,也适宜诊断CIS)。
The urothelial lining is increased in thickness and is still in general fairly organized (the cells are still mostly polarized with respect to the surface).
被覆的尿路上皮厚度增加,总体上仍然排列有序(细胞相对于表面仍然大部分极化)。
There is scattered subtle nuclear atypia consisting of random slightly enlarged darker nuclei, in contrast to PUNLMP, in which every nucleus looks the same.
散在分布的细微核非典型性,由随机分布的稍微增大的深染核组成。这与PUNLMP不同,PUNLMP中的每个核看起来都一样。
Mitoses are uncommon, but typically you will see some of them, in contrast to PUNLMP.
核分裂少见,但通常能找到一些核分裂象,这也与PUNLMP不同。
The urothelium is very disorderly, with little nuclear orientation to the surface.
尿路上皮排列非常乱,几乎没有核朝向表面。
Nuclei are enlarged, hyperchromatic, and pleomorphic and may have nucleoli (Figure 12.7).
核增大,深染,多形性,可能有核仁(图12.7)。
Mitoses are seen at all levels of the epithelium (in a well-oriented fragment).
上皮的所有层面都可见核分裂(要观察定向良好的片段)。
Focal nonurothelial differentiation (squamous or glandular) is possible.
可能出现局灶非尿路上皮分化(鳞状或腺样)。
A small amount of high-grade characteristics (>5%) generally defines the entire lesion as high grade.
只要少量高级别特征(>5%)通常就可以把整个病变定义为高级别。
Irregular tongues of cells or single cells pushing into the lamina propria
推挤并进入固有层的、不规则的细胞舌状突起或单个细胞
“Paradoxical differentiation”: the deep invasive cells acquire increased pink cytoplasm, mimicking maturing surface cells (Figure 12.8)
“反常分化”:深部浸润的细胞获得增多的粉红色细胞质,貌似成熟的表面细胞(图12.8)
Retraction artifact: the apparent cracking of the stroma away from tumor nests
收缩假象:肿瘤巢与间质之间明显开裂
Desmoplastic response of stroma (however, often not present)
促结缔组织增生性间质反应(但通常不存在)
Conditions that look like cancer but are not
似癌非癌(看起来像癌但不是癌的情况)
似良非良(看起来是良性但不是良性的情况)
Conditions that look benign but are not
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