甲状腺手术患者术后联合使用右美托咪定和氟比洛芬酯的好处
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Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery
背景与目的
本研究的目的是研究全麻手术患者联合使用右美托咪定（Dex）和氟比洛芬酯（FA）对术后镇痛，免疫反应以及认知功能的影响。
方 法
研究共纳入100名甲状腺手术患者并随机分为4组：Dex（D）组，FA（F）组，Dex联合FA（DF）组，生理盐水对照（C）组。
结 果
拔管时间和复苏时间，D组和DF组长于C组和F组。拔管后的心率和平均动脉压，F组和D组以及DF组显著低于C组，而DF组显著低于F组。视觉疼痛评分和瑞克镇静躁动评分，DF组显著低于其余三组。T淋巴细胞和B淋巴细胞数量，DF组显著高于其余三组。与F组C组比较，DF组的TNF-
和IL-6含量显著减少，但IL-2含量显著增加。
结 论
全麻甲状腺手术患者联合使用Dex和FA能显著降低术后疼痛，减少术后躁动和认知功能障碍，增强免疫功能并促进创口愈合。
原始文献摘要
Ma X, Li B, Wang D, et al. Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery.[J]. Experimental and therapeutic medicine, 2017,14(3):2148-2152. DOI:10.3892/etm.2017.4717
PURPOSE:The present study determined the effect of dexmedetomidine (Dex) combined with flurbiprofen axetil (FA) on analgesia, immune response, and preservation of cognitive function in patients subjected to general anesthesia.
METHODS:We recruited 100 patients with thyroid surgery and randomly divided them into four groups: Dex (D), FA (F), Dex combined with FA (DF), and saline control (C).
RESULTS: The extubation and recovery times for Groups D and DF were significantly longer than for Groups F and C. After extubation, the heart rate and mean arterial pressure for Groups F, D, and DF were significantly lower than for Group C, and data for Group DF was significantly lower than for Group F. The visual analog scale and Riker sedation agitation scores were significantly lower in Group DF than for the other three groups. T- and B-lymphocytes were significantly higher in Group DF than in the other three groups. Compared with Groups F and C, the levels of TNF-alpha and IL-6 in Group DF were significantly reduced, while IL-2 markedly increased.
CONCLUSION:The combined use of Dex and FA significantly improved pain after general anesthesia thyroid surgery, reduced restlessness and postoperative cognitive dysfunction, enhanced immune function, and promoted wound repair.
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